35986

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4306614..4307434 Replicon chromosome
Accession NZ_AP022533
Organism Escherichia coli strain THO-006

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag JLF32_RS20700 Protein ID WP_001054379.1
Coordinates 4306614..4306871 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag JLF32_RS20705 Protein ID WP_000123957.1
Coordinates 4306883..4307434 (+) Length 184 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF32_RS20680 4302161..4303141 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JLF32_RS20685 4303724..4304830 - 1107 Protein_4051 DNA helicase -
JLF32_RS20690 4304893..4306040 + 1148 WP_085949154.1 IS3-like element ISEc52 family transposase -
JLF32_RS20695 4306073..4306237 + 165 Protein_4053 GNAT family N-acetyltransferase -
JLF32_RS20700 4306614..4306871 + 258 WP_001054379.1 YjhX family toxin Toxin
JLF32_RS20705 4306883..4307434 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
JLF32_RS20710 4307486..4308232 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
JLF32_RS20715 4308360..4308620 + 261 WP_000077645.1 hypothetical protein -
JLF32_RS20720 4308658..4308774 + 117 Protein_4058 VOC family protein -
JLF32_RS20725 4309019..4310140 + 1122 WP_000010833.1 M42 family metallopeptidase -
JLF32_RS20730 4310137..4310415 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JLF32_RS20735 4310427..4311740 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(19-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T35986 WP_001054379.1 NZ_AP022533:4306614-4306871 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T35986 NZ_AP022533:4306614-4306871 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT35986 WP_000123957.1 NZ_AP022533:4306883-4307434 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp

>AT35986 NZ_AP022533:4306883-4307434 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB B6I030


Antitoxin

Source ID Structure

References