Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4713555..4714356 Replicon chromosome
Accession NZ_AP022525
Organism Escherichia coli strain THO-003

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag JLF28_RS23170 Protein ID WP_001094436.1
Coordinates 4713979..4714356 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag JLF28_RS23165 Protein ID WP_015953067.1
Coordinates 4713555..4713932 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF28_RS23130 4709466..4710146 + 681 WP_001282919.1 WYL domain-containing protein -
JLF28_RS23135 4710294..4710971 + 678 WP_001097301.1 hypothetical protein -
JLF28_RS23140 4710977..4711210 + 234 WP_001278287.1 DUF905 family protein -
JLF28_RS23145 4711300..4712118 + 819 WP_001175163.1 DUF945 domain-containing protein -
JLF28_RS23150 4712210..4712695 + 486 WP_029700724.1 antirestriction protein -
JLF28_RS23155 4712710..4713186 + 477 WP_001186756.1 RadC family protein -
JLF28_RS23160 4713255..4713476 + 222 WP_000692312.1 DUF987 domain-containing protein -
JLF28_RS23165 4713555..4713932 + 378 WP_015953067.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JLF28_RS23170 4713979..4714356 + 378 WP_001094436.1 TA system toxin CbtA family protein Toxin
JLF28_RS23175 4714353..4714841 + 489 WP_000761714.1 hypothetical protein -
JLF28_RS23180 4714853..4715050 + 198 WP_000839254.1 DUF957 domain-containing protein -
JLF28_RS23185 4715135..4715830 + 696 Protein_4550 DUF4942 domain-containing protein -
JLF28_RS23190 4715894..4716649 - 756 WP_000065240.1 IS21-like element ISEc10 family helper ATPase IstB -
JLF28_RS23195 4716646..4718145 - 1500 WP_029700729.1 IS21-like element ISEc10 family transposase -
JLF28_RS23200 4718236..4718397 + 162 Protein_4553 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T35935 WP_001094436.1 NZ_AP022525:4713979-4714356 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

>T35935 NZ_AP022525:4713979-4714356 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT35935 WP_015953067.1 NZ_AP022525:4713555-4713932 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT35935 NZ_AP022525:4713555-4713932 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L1N0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z3CIS0

References