Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1943655..1944486 Replicon chromosome
Accession NZ_AP022525
Organism Escherichia coli strain THO-003

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag JLF28_RS09175 Protein ID WP_000854815.1
Coordinates 1943655..1944029 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag JLF28_RS09180 Protein ID WP_001280918.1
Coordinates 1944118..1944486 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF28_RS09135 1939051..1940217 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JLF28_RS09140 1940336..1940809 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
JLF28_RS09145 1941007..1942065 + 1059 WP_001200889.1 FUSC family protein -
JLF28_RS09150 1942237..1942566 + 330 WP_000450409.1 DUF496 family protein -
JLF28_RS09155 1942667..1942849 - 183 WP_001296208.1 hypothetical protein -
JLF28_RS09160 1942903..1943049 + 147 Protein_1794 transposase domain-containing protein -
JLF28_RS09165 1943338..1943451 - 114 WP_001161660.1 DUF957 domain-containing protein -
JLF28_RS09170 1943464..1943658 - 195 WP_000988600.1 hypothetical protein -
JLF28_RS09175 1943655..1944029 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
JLF28_RS09180 1944118..1944486 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLF28_RS09185 1944502..1945146 - 645 WP_000086752.1 hypothetical protein -
JLF28_RS09190 1945165..1945386 - 222 WP_000692345.1 DUF987 domain-containing protein -
JLF28_RS09195 1945449..1945925 - 477 WP_001186200.1 RadC family protein -
JLF28_RS09200 1945941..1946414 - 474 WP_001542276.1 antirestriction protein -
JLF28_RS09205 1946508..1946753 - 246 WP_001164966.1 hypothetical protein -
JLF28_RS09210 1946753..1947571 - 819 WP_001542275.1 DUF945 domain-containing protein -
JLF28_RS09215 1947792..1948202 - 411 WP_000846703.1 hypothetical protein -
JLF28_RS09220 1948218..1948568 - 351 Protein_1806 hypothetical protein -
JLF28_RS09225 1948651..1949397 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T35917 WP_000854815.1 NZ_AP022525:c1944029-1943655 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T35917 NZ_AP022525:c1944029-1943655 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT35917 WP_001280918.1 NZ_AP022525:c1944486-1944118 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT35917 NZ_AP022525:c1944486-1944118 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References