Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4045224..4045881 Replicon chromosome
Accession NZ_AP022519
Organism Enterobacter cloacae strain STN0717-73

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag JLF40_RS19470 Protein ID WP_021242050.1
Coordinates 4045224..4045634 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag JLF40_RS19475 Protein ID WP_010435322.1
Coordinates 4045615..4045881 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF40_RS19450 4041217..4042950 - 1734 WP_033146589.1 single-stranded-DNA-specific exonuclease RecJ -
JLF40_RS19455 4042956..4043669 - 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLF40_RS19460 4043698..4044594 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
JLF40_RS19465 4044696..4045217 + 522 WP_023309099.1 flavodoxin FldB -
JLF40_RS19470 4045224..4045634 - 411 WP_021242050.1 protein YgfX Toxin
JLF40_RS19475 4045615..4045881 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
JLF40_RS19480 4046176..4047156 + 981 WP_033146590.1 tRNA-modifying protein YgfZ -
JLF40_RS19485 4047231..4047890 - 660 WP_033146591.1 hemolysin III family protein -
JLF40_RS19490 4048056..4048367 - 312 WP_033146592.1 N(4)-acetylcytidine aminohydrolase -
JLF40_RS19495 4048419..4049150 + 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
JLF40_RS19500 4049267..4050700 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T35906 WP_021242050.1 NZ_AP022519:c4045634-4045224 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T35906 NZ_AP022519:c4045634-4045224 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTTCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT35906 WP_010435322.1 NZ_AP022519:c4045881-4045615 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT35906 NZ_AP022519:c4045881-4045615 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References