Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3134644..3135234 Replicon chromosome
Accession NZ_AP022519
Organism Enterobacter cloacae strain STN0717-73

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JLF40_RS15245 Protein ID WP_033145927.1
Coordinates 3134644..3134976 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag JLF40_RS15250 Protein ID WP_033145928.1
Coordinates 3134977..3135234 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF40_RS15225 3129805..3130608 - 804 WP_003036327.1 TIGR02391 family protein -
JLF40_RS15230 3130630..3131109 - 480 WP_031617716.1 hypothetical protein -
JLF40_RS15235 3131188..3132126 - 939 WP_003036321.1 hypothetical protein -
JLF40_RS15240 3132962..3134323 + 1362 WP_003036316.1 hypothetical protein -
JLF40_RS15245 3134644..3134976 - 333 WP_033145927.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JLF40_RS15250 3134977..3135234 - 258 WP_033145928.1 antitoxin Antitoxin
JLF40_RS15255 3135526..3135915 - 390 WP_033145929.1 RidA family protein -
JLF40_RS15260 3136057..3136977 + 921 WP_033145930.1 LysR family transcriptional regulator -
JLF40_RS15265 3137053..3137355 - 303 WP_029741460.1 XRE family transcriptional regulator -
JLF40_RS15270 3137360..3137713 - 354 WP_033145931.1 type II toxin-antitoxin system RelE/ParE family toxin -
JLF40_RS15275 3137891..3138784 - 894 WP_033145932.1 LysR family transcriptional regulator -
JLF40_RS15280 3138955..3139563 + 609 WP_080277780.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11828.65 Da        Isoelectric Point: 9.4051

>T35902 WP_033145927.1 NZ_AP022519:c3134976-3134644 [Enterobacter cloacae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMSARNGMRLERIPDAVINEVLARLDAILN

Download         Length: 333 bp

>T35902 NZ_AP022519:c3134976-3134644 [Enterobacter cloacae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTAGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACCGTTTCACTGGAAGGGGCGGGAACAACAACAACGGGCGTTATTCGCTGCGATCAGCCCAGAACCATT
GATATGTCTGCCCGGAACGGCATGCGGCTGGAACGTATACCTGACGCGGTTATAAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTGAATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9464.92 Da        Isoelectric Point: 4.4737

>AT35902 WP_033145928.1 NZ_AP022519:c3135234-3134977 [Enterobacter cloacae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp

>AT35902 NZ_AP022519:c3135234-3134977 [Enterobacter cloacae]
ATGTATACAACTCGTCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAACT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAGCGGCCTCACTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGCGAAGAGGAGCGGGAATGGATCGATGCGCCTGCGGTG
GGCAGGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References