Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4757833..4758421 Replicon chromosome
Accession NZ_AP022513
Organism Citrobacter portucalensis strain STN0717-72

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag JLF48_RS22885 Protein ID WP_063941209.1
Coordinates 4757833..4758150 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag JLF48_RS22890 Protein ID WP_032942057.1
Coordinates 4758143..4758421 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF48_RS22860 4753601..4754425 + 825 WP_200920925.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JLF48_RS22865 4754494..4755717 + 1224 WP_200920926.1 zinc-binding dehydrogenase -
JLF48_RS22870 4755719..4756531 + 813 WP_063941212.1 shikimate 5-dehydrogenase -
JLF48_RS22875 4756581..4756886 - 306 WP_032934126.1 hypothetical protein -
JLF48_RS22880 4757018..4757569 + 552 WP_200920927.1 AAA family ATPase -
JLF48_RS22885 4757833..4758150 + 318 WP_063941209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLF48_RS22890 4758143..4758421 + 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
JLF48_RS22895 4758532..4759221 + 690 WP_200921622.1 dipeptidase PepE -
JLF48_RS22900 4759336..4760967 - 1632 WP_003826514.1 Na/Pi cotransporter family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.09 Da        Isoelectric Point: 10.1413

>T35884 WP_063941209.1 NZ_AP022513:4757833-4758150 [Citrobacter portucalensis]
IMEILQTMVFRRWEQNLRDRRAKTLIATRLFRLANGLSGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARSLDYQEVFRHE

Download         Length: 318 bp

>T35884 NZ_AP022513:4757833-4758150 [Citrobacter portucalensis]
ATCATGGAAATTCTTCAGACAATGGTTTTCCGGCGTTGGGAGCAAAACCTACGGGACAGGAGAGCTAAAACGCTCATTGC
CACACGCCTTTTTCGTTTGGCTAATGGTTTATCTGGTGATGTAAAACCTGTTGGGGAAGGCGTCAGCGAAATGCGCATTT
CTTACGGTCCTGGCTACAGGATTTACTTTAAACAGCAAGGCTGCCGCATCATCATTTTGTTATGTGGGGGCGATAAAAGC
TCACAAGCCAACGATATTACTCTTGCAAAAATGCTTGCCCGTTCACTGGATTATCAGGAGGTCTTCCGCCATGAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT35884 WP_032942057.1 NZ_AP022513:4758143-4758421 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT35884 NZ_AP022513:4758143-4758421 [Citrobacter portucalensis]
ATGAATAAACTTACTCACTACGATCCCGCGACTGCGCTGGTTGATGATGAAGAAATTGCCGTGTTTATGGCCGATGCCCT
CGAAACAGGTGATGCAGCATACATTGCAAAAGCACTGGGCGTGGTGGCTCGTGCTAAGGGTATGGCGAACATCGCAGCAG
AAACGGGATTATCCCGCGAGCAGCTTTATCGCTCTTTTAGTGAGAAAGGTAACCCGACGCTGAAAACCACACTTGCGGTG
ATGAAGGTGCTCGGTATTGAATTGACACTTAAAAAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References