Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 1648983..1649517 | Replicon | chromosome |
Accession | NZ_AP022513 | ||
Organism | Citrobacter portucalensis strain STN0717-72 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A6P1V8P2 |
Locus tag | JLF48_RS07780 | Protein ID | WP_000143805.1 |
Coordinates | 1649227..1649517 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A7I6XZR7 |
Locus tag | JLF48_RS07775 | Protein ID | WP_000104338.1 |
Coordinates | 1648983..1649237 (+) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JLF48_RS07760 | 1645647..1646627 | + | 981 | WP_033146059.1 | IS5-like element ISKpn26 family transposase | - |
JLF48_RS07765 | 1647634..1648029 | + | 396 | WP_032637393.1 | hypothetical protein | - |
JLF48_RS07770 | 1648116..1648826 | + | 711 | WP_032637325.1 | tyrosine-type recombinase/integrase | - |
JLF48_RS07775 | 1648983..1649237 | + | 255 | WP_000104338.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
JLF48_RS07780 | 1649227..1649517 | + | 291 | WP_000143805.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JLF48_RS07785 | 1649599..1650546 | - | 948 | WP_023356254.1 | IS30 family transposase | - |
JLF48_RS07790 | 1650651..1651457 | - | 807 | Protein_1530 | glucosyl transferase GtrII family protein | - |
JLF48_RS07795 | 1651594..1652574 | - | 981 | WP_200923080.1 | IS5 family transposase | - |
JLF48_RS07800 | 1652643..1653371 | - | 729 | Protein_1532 | IS5-like element ISEc68 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | wbbO / wbbN / glf / wzm | 1629970..1659992 | 30022 | |
- | inside | IScluster/Tn | - | - | 1643190..1657234 | 14044 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11463.41 Da Isoelectric Point: 10.2689
>T35872 WP_000143805.1 NZ_AP022513:1649227-1649517 [Citrobacter portucalensis]
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL
Download Length: 291 bp
>T35872 NZ_AP022513:1649227-1649517 [Citrobacter portucalensis]
ATGACCTTTAATGTTGAATTTGACGAAAGGGCGTTTAAGGAATGGAATAAGCTCGAAAAGACGATCCGTGAGCAATTCAA
AAAGAAGCTAAAAAAGCTTCAGCAAAATCCTTATGTGGAATCAGCCCGACTGCATGGTGATCTGGCTGGCTGCTTTAAAA
TAAAGCTGAGAGCATCTGGTTTTCGTTTGATTTACAAGGTTATCGATGACGAGATTGTTATATGGGTGGTCGCAGTAGGT
AAACGGGAAGACGAAAAAGCCTATGAAACGGCCCGAAAGCGTCTTTTATAA
ATGACCTTTAATGTTGAATTTGACGAAAGGGCGTTTAAGGAATGGAATAAGCTCGAAAAGACGATCCGTGAGCAATTCAA
AAAGAAGCTAAAAAAGCTTCAGCAAAATCCTTATGTGGAATCAGCCCGACTGCATGGTGATCTGGCTGGCTGCTTTAAAA
TAAAGCTGAGAGCATCTGGTTTTCGTTTGATTTACAAGGTTATCGATGACGAGATTGTTATATGGGTGGTCGCAGTAGGT
AAACGGGAAGACGAAAAAGCCTATGAAACGGCCCGAAAGCGTCTTTTATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9708.04 Da Isoelectric Point: 4.4247
>AT35872 WP_000104338.1 NZ_AP022513:1648983-1649237 [Citrobacter portucalensis]
MSTIQIRVDDELKKDAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL
MSTIQIRVDDELKKDAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL
Download Length: 255 bp
>AT35872 NZ_AP022513:1648983-1649237 [Citrobacter portucalensis]
ATGAGCACAATTCAAATCCGCGTTGATGACGAACTGAAAAAAGACGCCTATCAGGCCTTTGAAAAACTGAATCTGTCGCC
TTCAGACGCACTTCGTCTGTTCCTGCGGTATGTCGCAGAGAACGAAAAACTCCCCTTTGCTGAAGTCTCAGTGATGGTGA
GCGAAGATGATGAAGACGCTGATATTCTGGCAGTGGTTCGGGAAAGACTGAAAAATCCGGCAAGACGGATCAGGGTTAAC
GTTGATGACCTTTAA
ATGAGCACAATTCAAATCCGCGTTGATGACGAACTGAAAAAAGACGCCTATCAGGCCTTTGAAAAACTGAATCTGTCGCC
TTCAGACGCACTTCGTCTGTTCCTGCGGTATGTCGCAGAGAACGAAAAACTCCCCTTTGCTGAAGTCTCAGTGATGGTGA
GCGAAGATGATGAAGACGCTGATATTCTGGCAGTGGTTCGGGAAAGACTGAAAAATCCGGCAAGACGGATCAGGGTTAAC
GTTGATGACCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6P1V8P2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7I6XZR7 |