Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1395663..1396283 Replicon chromosome
Accession NZ_AP022513
Organism Citrobacter portucalensis strain STN0717-72

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JLF48_RS06595 Protein ID WP_002892050.1
Coordinates 1396065..1396283 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag JLF48_RS06590 Protein ID WP_003021733.1
Coordinates 1395663..1396037 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF48_RS06580 1390809..1392002 + 1194 WP_003831044.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JLF48_RS06585 1392025..1395174 + 3150 WP_193135115.1 efflux RND transporter permease AcrB -
JLF48_RS06590 1395663..1396037 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
JLF48_RS06595 1396065..1396283 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JLF48_RS06600 1396465..1397016 + 552 WP_003835924.1 maltose O-acetyltransferase -
JLF48_RS06605 1397133..1397603 + 471 WP_003021724.1 YlaC family protein -
JLF48_RS06610 1397682..1397822 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
JLF48_RS06615 1397824..1398084 - 261 WP_008783961.1 type B 50S ribosomal protein L31 -
JLF48_RS06620 1398273..1399826 + 1554 WP_200920716.1 EAL domain-containing protein -
JLF48_RS06625 1399878..1400231 - 354 WP_003831033.1 DUF1428 family protein -
JLF48_RS06630 1400296..1400925 - 630 WP_003831032.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T35870 WP_002892050.1 NZ_AP022513:1396065-1396283 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T35870 NZ_AP022513:1396065-1396283 [Citrobacter portucalensis]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT35870 WP_003021733.1 NZ_AP022513:1395663-1396037 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT35870 NZ_AP022513:1395663-1396037 [Citrobacter portucalensis]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTTAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References