Detailed information of TA system TA035867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 60369..60935
• Replicon: chromosome
• Accession: NZ_AP022513
• Organism: Citrobacter portucalensis strain STN0717-72

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JLF48_RS00305
• Protein ID: WP_200920966.1
• Coordinates: 60369..60671 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7I6X5E4
• Locus tag: JLF48_RS00310
• Protein ID: WP_008786497.1
• Coordinates: 60675..60935 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLF48_RS00285	56021..58801	+	2781	WP_200920964.1	intestinal colonization autotransporter adhesin MisL	-
JLF48_RS00290	58894..59226	-	333	WP_003827189.1	DUF1493 family protein	-
JLF48_RS00295	59220..59663	-	444	Protein_58	hypothetical protein	-
JLF48_RS00300	59674..60159	-	486	WP_200920965.1	type VI secretion system tube protein Hcp	-
JLF48_RS00305	60369..60671	-	303	WP_200920966.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JLF48_RS00310	60675..60935	-	261	WP_008786497.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JLF48_RS00315	61110..61400	-	291	WP_197385420.1	SymE family type I addiction module toxin	-
JLF48_RS00320	61537..61731	+	195	WP_003827195.1	toxin-antitoxin system HicB family antitoxin	-
JLF48_RS00325	61740..62296	-	557	Protein_64	hypothetical protein	-
JLF48_RS00335	62790..64172	+	1383	WP_200920967.1	glycoside-pentoside-hexuronide family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11621.25 Da
• Isoelectric Point: 8.0883

>T35867 WP_200920966.1 NZ_AP022513:c60671-60369 [Citrobacter portucalensis]
VSYKLTGEAQHDIIEIRDYTSRNWGAKQSKDYLRKLQVVLSQLAEMPGMGHHRINDFCEDIYSFPYVSHMIYYSAQDTNI
VVLAVLHQSRVPTKHLGQRL

Nucleotide

• Length: 303 bp

>T35867 NZ_AP022513:c60671-60369 [Citrobacter portucalensis]
GTGAGTTACAAACTTACTGGAGAAGCACAGCACGATATTATTGAAATCCGTGATTACACATCAAGAAATTGGGGCGCTAA
ACAGTCCAAGGATTATCTTAGAAAATTACAGGTCGTTCTCTCTCAGTTAGCTGAAATGCCAGGCATGGGTCATCATCGAA
TTAATGATTTTTGTGAAGATATTTACAGCTTTCCTTATGTTAGCCATATGATTTACTACAGTGCACAAGACACAAATATT
GTTGTACTGGCAGTCTTACACCAAAGCCGAGTACCAACAAAACATCTGGGACAACGTTTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9736.15 Da
• Isoelectric Point: 5.5882

>AT35867 WP_008786497.1 NZ_AP022513:c60935-60675 [Citrobacter portucalensis]
MHTLTANEAKTQFGDMLLKAQREPVQINRNGKPVAVVVSIEDYEQMEAMKLQLLKAKIQRAQNDIHLGNIVDGDAFFDEL
MDQHKG

Nucleotide

• Length: 261 bp

>AT35867 NZ_AP022513:c60935-60675 [Citrobacter portucalensis]
ATGCATACTCTTACGGCAAATGAAGCCAAAACCCAGTTTGGCGATATGCTACTTAAAGCGCAGCGAGAGCCAGTGCAAAT
TAACCGTAACGGTAAGCCTGTTGCAGTTGTTGTTTCCATTGAAGACTATGAACAAATGGAAGCCATGAAGCTCCAGTTAC
TGAAGGCCAAAATTCAGCGTGCTCAAAACGATATTCATTTGGGCAATATTGTTGATGGTGATGCTTTTTTTGATGAGTTG
ATGGATCAACACAAAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A7I6X5E4