Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 191840..192366 | Replicon | plasmid pSTN0717-64-1 |
Accession | NZ_AP022511 | ||
Organism | Enterobacter hormaechei strain STN0717-64 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | JLF41_RS24760 | Protein ID | WP_000323025.1 |
Coordinates | 191840..192127 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | JLF41_RS24765 | Protein ID | WP_000534858.1 |
Coordinates | 192127..192366 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JLF41_RS24725 | 187410..187586 | - | 177 | WP_001371930.1 | hypothetical protein | - |
JLF41_RS24730 | 188097..189041 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
JLF41_RS24735 | 189140..189739 | + | 600 | WP_001031420.1 | hypothetical protein | - |
JLF41_RS24740 | 189799..190149 | + | 351 | WP_000743059.1 | hypothetical protein | - |
JLF41_RS24745 | 190196..190399 | + | 204 | WP_001015183.1 | hypothetical protein | - |
JLF41_RS24750 | 190681..191001 | + | 321 | WP_000332796.1 | hypothetical protein | - |
JLF41_RS24755 | 191610..191768 | - | 159 | WP_001447866.1 | type I toxin-antitoxin system Hok family toxin | - |
JLF41_RS24760 | 191840..192127 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
JLF41_RS24765 | 192127..192366 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
JLF41_RS24770 | 192629..193552 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
JLF41_RS24775 | 193752..194324 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
JLF41_RS24780 | 194429..195133 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
JLF41_RS24785 | 195394..195591 | + | 198 | WP_078310596.1 | DDE-type integrase/transposase/recombinase | - |
JLF41_RS24790 | 195955..196596 | - | 642 | WP_013851373.1 | tetracycline resistance transcriptional repressor TetR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | ant(2'')-Ia / aadA2 / qacE / sul1 / blaCTX-M-9 / mcr-9 / tet(A) / dfrA16 / qnrA1 / catA1 | - | 1..292755 | 292755 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T35866 WP_000323025.1 NZ_AP022511:c192127-191840 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T35866 NZ_AP022511:c192127-191840 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT35866 WP_000534858.1 NZ_AP022511:c192366-192127 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT35866 NZ_AP022511:c192366-192127 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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