35866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 191840..192366 Replicon plasmid pSTN0717-64-1
Accession NZ_AP022511
Organism Enterobacter hormaechei strain STN0717-64

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JLF41_RS24760 Protein ID WP_000323025.1
Coordinates 191840..192127 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JLF41_RS24765 Protein ID WP_000534858.1
Coordinates 192127..192366 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF41_RS24725 187410..187586 - 177 WP_001371930.1 hypothetical protein -
JLF41_RS24730 188097..189041 + 945 WP_000778029.1 DUF5417 domain-containing protein -
JLF41_RS24735 189140..189739 + 600 WP_001031420.1 hypothetical protein -
JLF41_RS24740 189799..190149 + 351 WP_000743059.1 hypothetical protein -
JLF41_RS24745 190196..190399 + 204 WP_001015183.1 hypothetical protein -
JLF41_RS24750 190681..191001 + 321 WP_000332796.1 hypothetical protein -
JLF41_RS24755 191610..191768 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
JLF41_RS24760 191840..192127 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JLF41_RS24765 192127..192366 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JLF41_RS24770 192629..193552 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
JLF41_RS24775 193752..194324 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
JLF41_RS24780 194429..195133 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
JLF41_RS24785 195394..195591 + 198 WP_078310596.1 DDE-type integrase/transposase/recombinase -
JLF41_RS24790 195955..196596 - 642 WP_013851373.1 tetracycline resistance transcriptional repressor TetR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(2'')-Ia / aadA2 / qacE / sul1 / blaCTX-M-9 / mcr-9 / tet(A) / dfrA16 / qnrA1 / catA1 - 1..292755 292755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T35866 WP_000323025.1 NZ_AP022511:c192127-191840 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T35866 NZ_AP022511:c192127-191840 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT35866 WP_000534858.1 NZ_AP022511:c192366-192127 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT35866 NZ_AP022511:c192366-192127 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References