Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2488977..2489716 Replicon chromosome
Accession NZ_AP022510
Organism Enterobacter hormaechei strain STN0717-64

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag JLF41_RS11965 Protein ID WP_003857133.1
Coordinates 2488977..2489462 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag JLF41_RS11970 Protein ID WP_003857131.1
Coordinates 2489450..2489716 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF41_RS11940 2484221..2484835 + 615 WP_065420578.1 NUDIX hydrolase -
JLF41_RS11945 2485033..2485665 + 633 WP_001567369.1 hypothetical protein -
JLF41_RS11950 2485694..2487097 - 1404 WP_039815096.1 ISNCY-like element ISKpn21 family transposase -
JLF41_RS11955 2487376..2488341 + 966 WP_032648329.1 hypothetical protein -
JLF41_RS11960 2488357..2488926 + 570 WP_032648331.1 hypothetical protein -
JLF41_RS11965 2488977..2489462 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
JLF41_RS11970 2489450..2489716 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
JLF41_RS11975 2489780..2490709 - 930 WP_032648334.1 LysR family transcriptional regulator -
JLF41_RS11980 2490839..2492221 + 1383 WP_032648336.1 MFS transporter -
JLF41_RS11985 2492243..2493238 - 996 WP_017382342.1 DUF2891 domain-containing protein -
JLF41_RS11990 2493248..2494234 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2485694..2487097 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T35853 WP_003857133.1 NZ_AP022510:c2489462-2488977 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T35853 NZ_AP022510:c2489462-2488977 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT35853 WP_003857131.1 NZ_AP022510:c2489716-2489450 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT35853 NZ_AP022510:c2489716-2489450 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References