Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | KacT-ataR/DUF1778(antitoxin) |
| Location | 1869173..1869970 | Replicon | chromosome |
| Accession | NZ_AP022510 | ||
| Organism | Enterobacter hormaechei strain STN0717-64 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | A0A222RDD1 |
| Locus tag | JLF41_RS08865 | Protein ID | WP_032647926.1 |
| Coordinates | 1869449..1869970 (+) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | - |
| Locus tag | JLF41_RS08860 | Protein ID | WP_202190766.1 |
| Coordinates | 1869173..1869442 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JLF41_RS08825 | 1864713..1865072 | + | 360 | WP_032647921.1 | helix-turn-helix transcriptional regulator | - |
| JLF41_RS08830 | 1865082..1865246 | - | 165 | WP_017693668.1 | helix-turn-helix transcriptional regulator | - |
| JLF41_RS08835 | 1865399..1866640 | + | 1242 | WP_032647923.1 | bifunctional glucose-1-phosphatase/inositol phosphatase | - |
| JLF41_RS08840 | 1866673..1866900 | - | 228 | WP_006809324.1 | YccJ family protein | - |
| JLF41_RS08845 | 1866919..1867515 | - | 597 | WP_006809323.1 | NAD(P)H:quinone oxidoreductase | - |
| JLF41_RS08850 | 1867907..1868077 | + | 171 | WP_001273664.1 | general stress protein | - |
| JLF41_RS08855 | 1868194..1869099 | + | 906 | WP_017693666.1 | DMT family transporter | - |
| JLF41_RS08860 | 1869173..1869442 | + | 270 | WP_202190766.1 | DUF1778 domain-containing protein | Antitoxin |
| JLF41_RS08865 | 1869449..1869970 | + | 522 | WP_032647926.1 | GNAT family N-acetyltransferase | Toxin |
| JLF41_RS08870 | 1870029..1871351 | - | 1323 | WP_032647928.1 | pyrimidine utilization transport protein G | - |
| JLF41_RS08875 | 1871373..1871864 | - | 492 | WP_032647931.1 | pyrimidine utilization flavin reductase protein F | - |
| JLF41_RS08880 | 1871877..1872467 | - | 591 | WP_032647932.1 | malonic semialdehyde reductase | - |
| JLF41_RS08885 | 1872477..1873277 | - | 801 | WP_032647935.1 | pyrimidine utilization protein D | - |
| JLF41_RS08890 | 1873285..1873671 | - | 387 | WP_015570870.1 | pyrimidine utilization protein C | - |
| JLF41_RS08895 | 1873683..1874372 | - | 690 | WP_017384771.1 | pyrimidine utilization protein B | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19451.21 Da Isoelectric Point: 7.4318
>T35852 WP_032647926.1 NZ_AP022510:1869449-1869970 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
Download Length: 522 bp
>T35852 NZ_AP022510:1869449-1869970 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10237.71 Da Isoelectric Point: 5.8836
>AT35852 WP_202190766.1 NZ_AP022510:1869173-1869442 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNSPEPNERLKR
AAKRLRNME
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNSPEPNERLKR
AAKRLRNME
Download Length: 270 bp
>AT35852 NZ_AP022510:1869173-1869442 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATTCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATTCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|