Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1221757..1222377 Replicon chromosome
Accession NZ_AP022510
Organism Enterobacter hormaechei strain STN0717-64

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag JLF41_RS05760 Protein ID WP_015571250.1
Coordinates 1221757..1221975 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag JLF41_RS05765 Protein ID WP_006809850.1
Coordinates 1222003..1222377 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF41_RS05730 1217769..1218029 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
JLF41_RS05735 1218032..1218172 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JLF41_RS05740 1218169..1218879 - 711 WP_032647453.1 GNAT family N-acetyltransferase -
JLF41_RS05745 1218981..1220441 + 1461 WP_032647455.1 PLP-dependent aminotransferase family protein -
JLF41_RS05750 1220413..1220880 - 468 WP_015571252.1 extracytoplasmic function sigma factor YlaC -
JLF41_RS05755 1220997..1221548 - 552 WP_032647457.1 maltose O-acetyltransferase -
JLF41_RS05760 1221757..1221975 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
JLF41_RS05765 1222003..1222377 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
JLF41_RS05770 1222888..1226034 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
JLF41_RS05775 1226057..1227250 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T35850 WP_015571250.1 NZ_AP022510:c1221975-1221757 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T35850 NZ_AP022510:c1221975-1221757 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT35850 WP_006809850.1 NZ_AP022510:c1222377-1222003 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT35850 NZ_AP022510:c1222377-1222003 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References