35845

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3791170..3791827 Replicon chromosome
Accession NZ_AP022508
Organism Enterobacter bugandensis strain STN0717-56

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag JLD64_RS17890 Protein ID WP_028014322.1
Coordinates 3791170..3791580 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag JLD64_RS17895 Protein ID WP_010435322.1
Coordinates 3791561..3791827 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLD64_RS17870 3787163..3788896 - 1734 WP_028014318.1 single-stranded-DNA-specific exonuclease RecJ -
JLD64_RS17875 3788902..3789615 - 714 WP_028014319.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLD64_RS17880 3789644..3790540 - 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
JLD64_RS17885 3790642..3791163 + 522 WP_028014321.1 flavodoxin FldB -
JLD64_RS17890 3791170..3791580 - 411 WP_028014322.1 protein YgfX Toxin
JLD64_RS17895 3791561..3791827 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
JLD64_RS17900 3792122..3793102 + 981 WP_199886713.1 tRNA-modifying protein YgfZ -
JLD64_RS17905 3793190..3793849 - 660 WP_023331242.1 hemolysin III family protein -
JLD64_RS17910 3794115..3794846 + 732 WP_136343846.1 MurR/RpiR family transcriptional regulator -
JLD64_RS17915 3794963..3796396 + 1434 WP_028014326.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T35845 WP_028014322.1 NZ_AP022508:c3791580-3791170 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T35845 NZ_AP022508:c3791580-3791170 [Enterobacter bugandensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CATCGTTTTACTCATGCCGTGGCCGCTCAGCTATACGCCGCTGTGGCTGCTATTACTTTCGTTTGTTGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAACGCGCGTCAGGGCGAGATCAAGCTGTTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGACATTCTCGGTGTGCCCTGGATGCTTAACGCCGGGATGATGTTACGGTTACGCAAAGTGGGGGGCGGACGTTG
CCAGCACCTGTGGCTGGCGGCGGACAGTATGGACGCATCAGAATGGCGGGATCTGCGCCGGATGTTGCTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT35845 WP_010435322.1 NZ_AP022508:c3791827-3791561 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT35845 NZ_AP022508:c3791827-3791561 [Enterobacter bugandensis]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTACGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References