35843

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2976549..2977139 Replicon chromosome
Accession NZ_AP022508
Organism Enterobacter bugandensis strain STN0717-56

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JLD64_RS14190 Protein ID WP_028013735.1
Coordinates 2976549..2976881 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A8E1V487
Locus tag JLD64_RS14195 Protein ID WP_041909206.1
Coordinates 2976882..2977139 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLD64_RS14150 2972118..2972819 + 702 WP_023297911.1 hypothetical protein -
JLD64_RS14155 2972921..2973388 + 468 WP_200919962.1 DUF4756 family protein -
JLD64_RS14160 2973437..2973673 - 237 WP_023297909.1 hypothetical protein -
JLD64_RS14165 2973736..2974032 - 297 WP_023297908.1 hypothetical protein -
JLD64_RS14170 2974103..2974339 - 237 WP_000999357.1 hypothetical protein -
JLD64_RS14175 2974405..2974722 - 318 WP_200919963.1 hypothetical protein -
JLD64_RS14180 2974862..2975080 - 219 WP_032737122.1 AlpA family transcriptional regulator -
JLD64_RS14185 2975228..2976091 - 864 WP_004864372.1 hypothetical protein -
JLD64_RS14190 2976549..2976881 - 333 WP_028013735.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JLD64_RS14195 2976882..2977139 - 258 WP_041909206.1 antitoxin Antitoxin
JLD64_RS14200 2977417..2978376 - 960 WP_199886663.1 zinc-binding alcohol dehydrogenase family protein -
JLD64_RS14205 2978425..2978814 - 390 WP_059358451.1 RidA family protein -
JLD64_RS14210 2978956..2979876 + 921 WP_063437796.1 LysR family transcriptional regulator -
JLD64_RS14215 2980037..2981323 - 1287 WP_063437795.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11828.76 Da        Isoelectric Point: 10.2965

>T35843 WP_028013735.1 NZ_AP022508:c2976881-2976549 [Enterobacter bugandensis]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTKTMGVIRCDQPRTI
DMAARNGMRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

>T35843 NZ_AP022508:c2976881-2976549 [Enterobacter bugandensis]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTTCTCAT
CGTGTCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTAGTGGTTCCCGTCACCAGCGGCGGTAACTTTGCTCGCA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCGGGGACAAAAACGATGGGCGTTATTCGCTGCGACCAGCCCAGAACTATT
GATATGGCTGCCCGAAACGGCATGCGGCTGGAACGCATACCTGATGCCGTTGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTCTGAGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9449.95 Da        Isoelectric Point: 4.6234

>AT35843 WP_041909206.1 NZ_AP022508:c2977139-2976882 [Enterobacter bugandensis]
MYKTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT35843 NZ_AP022508:c2977139-2976882 [Enterobacter bugandensis]
ATGTATAAAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAACAATGGCTGCCTGATCATTGAACCCCAAAAACGGCCTCATTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGTGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTA
GGAAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References