Detailed information of TA system TA035832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 488523..489039
• Replicon: chromosome
• Accession: NZ_AP022508
• Organism: Enterobacter bugandensis strain STN0717-56

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JLD64_RS02415
• Protein ID: WP_041911453.1
• Coordinates: 488755..489039 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8E1RL94
• Locus tag: JLD64_RS02410
• Protein ID: WP_023331889.1
• Coordinates: 488523..488765 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLD64_RS02395	484613..485353	+	741	WP_199886957.1	KDGP aldolase family protein	-
JLD64_RS02400	485379..486515	+	1137	WP_199886956.1	lactonase family protein	-
JLD64_RS02405	486535..488445	+	1911	WP_047367003.1	BglG family transcription antiterminator	-
JLD64_RS02410	488523..488765	+	243	WP_023331889.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JLD64_RS02415	488755..489039	+	285	WP_041911453.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JLD64_RS02420	489043..489507	-	465	WP_049138568.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JLD64_RS02425	489593..491731	-	2139	WP_199886955.1	anaerobic ribonucleoside-triphosphate reductase	-
JLD64_RS02430	492101..492673	-	573	WP_126817961.1	fructose PTS transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11001.95 Da
• Isoelectric Point: 10.0526

>T35832 WP_041911453.1 NZ_AP022508:488755-489039 [Enterobacter bugandensis]
MIYELEFDPRALKEWHKLGDTVKCQFKKKLADVLVNPRIESARLHGLPDCYKIKLRSLGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHEANKRL

Nucleotide

• Length: 285 bp

>T35832 NZ_AP022508:488755-489039 [Enterobacter bugandensis]
ATGATTTATGAACTGGAGTTCGACCCGAGGGCTTTAAAGGAGTGGCATAAGCTGGGCGATACGGTGAAATGCCAGTTTAA
AAAGAAACTTGCTGACGTCTTAGTGAACCCCAGAATTGAATCGGCCCGCCTGCACGGCCTGCCGGATTGCTACAAAATAA
AACTCAGATCTCTGGGTTATCGTTTGGTTTATCAGGTTCAGGATAACGTAGTTACGGTATTTGTTATCGCTATCGGAAAG
AGAGAGAAATCAGCCGTTTATCATGAAGCAAATAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9030.41 Da
• Isoelectric Point: 4.7719

>AT35832 WP_023331889.1 NZ_AP022508:488523-488765 [Enterobacter bugandensis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDELIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT35832 NZ_AP022508:488523-488765 [Enterobacter bugandensis]
ATGGCCACGCTTAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCGTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCCGTGCGGTTACTGTTTCAGTACGTTGCGGAAACAGGGCGTATGCCGGTGAAAACTGTCACCATCAGTGACA
GTGAAGATGAACTGATACAGACAGTCCGGGAGCGACTGGCGAATCCACAAAAGGGAATTAAGGTTAGTCTGGATGATTTA
TGA