Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 147551..148158 Replicon chromosome
Accession NZ_AP022508
Organism Enterobacter bugandensis strain STN0717-56

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JLD64_RS00760 Protein ID WP_063943254.1
Coordinates 147551..147736 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JLD64_RS00765 Protein ID WP_193031577.1
Coordinates 147751..148158 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLD64_RS00740 142933..143817 - 885 WP_199887016.1 ROK family protein -
JLD64_RS00745 143983..145521 + 1539 WP_041911639.1 aldehyde dehydrogenase AldB -
JLD64_RS00750 145518..146483 - 966 WP_199887017.1 LysR family transcriptional regulator -
JLD64_RS00755 146601..147341 + 741 WP_028015056.1 MipA/OmpV family protein -
JLD64_RS00760 147551..147736 + 186 WP_063943254.1 type II toxin-antitoxin system HicA family toxin Toxin
JLD64_RS00765 147751..148158 + 408 WP_193031577.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JLD64_RS00770 148162..149238 - 1077 WP_182035321.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
JLD64_RS00775 149445..149551 - 107 Protein_153 class II aldolase/adducin family protein -
JLD64_RS00780 149632..151350 - 1719 WP_182035319.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
JLD64_RS00785 151441..152283 - 843 WP_182035317.1 collagen-like triple helix repeat-containing protein -
JLD64_RS00790 152280..152516 - 237 WP_182035315.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.01 Da        Isoelectric Point: 11.2341

>T35831 WP_063943254.1 NZ_AP022508:147551-147736 [Enterobacter bugandensis]
VKSADVITVLIGHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGALAQIWRQAGIKH

Download         Length: 186 bp

>T35831 NZ_AP022508:147551-147736 [Enterobacter bugandensis]
GTGAAAAGTGCGGATGTCATTACCGTTCTGATCGGCCACGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCATCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCTAAGAAGGATATTAAACCGGGCGCGCTCGCGCAGATAT
GGCGGCAGGCGGGAATTAAACACTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15103.86 Da        Isoelectric Point: 4.3282

>AT35831 WP_193031577.1 NZ_AP022508:147751-148158 [Enterobacter bugandensis]
MFYPAYIHSDTDGSASGFFPDVPGCFFAGDSLDDAFQDAREALTAHFEALFEMDEALPLPGNVEVHLENHPDDFTGGQWL
LVDINMRQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp

>AT35831 NZ_AP022508:147751-148158 [Enterobacter bugandensis]
ATGTTTTATCCGGCTTACATTCATTCTGACACCGACGGTAGCGCCAGCGGCTTTTTTCCTGACGTTCCAGGCTGTTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCACGTGAGGCGCTCACCGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTTCCGGGGAATGTCGAAGTGCACCTTGAAAATCACCCTGACGACTTCACGGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAGGCAGTTTGACGGCAGAGCCGAGCGTATCAACATCACGATGCCTCGACGTTTGCTGGTAAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTGGCTGAGGCAGCACGTCGCGTGCTGC
CTGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References