Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 642796..643549 Replicon chromosome
Accession NZ_AP022486
Organism Citrobacter portucalensis strain STN0717-27

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag JLF36_RS03100 Protein ID WP_025799003.1
Coordinates 643172..643549 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag JLF36_RS03095 Protein ID WP_072269511.1
Coordinates 642796..643122 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF36_RS03075 638204..641359 + 3156 WP_077267777.1 AIDA repeat-containing protein -
JLF36_RS03080 641582..642013 + 432 WP_088903392.1 antirestriction protein -
JLF36_RS03085 642025..642504 + 480 WP_025798999.1 DNA repair protein RadC -
JLF36_RS03090 642518..642739 + 222 WP_045888217.1 DUF987 domain-containing protein -
JLF36_RS03095 642796..643122 + 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLF36_RS03100 643172..643549 + 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
JLF36_RS03105 643546..644037 + 492 WP_045888216.1 hypothetical protein -
JLF36_RS03110 644066..644269 + 204 WP_025799007.1 DUF957 domain-containing protein -
JLF36_RS03115 644351..645196 + 846 WP_025799009.1 DUF4942 domain-containing protein -
JLF36_RS03125 645500..646006 + 507 WP_149281949.1 G/U mismatch-specific DNA glycosylase -
JLF36_RS03130 646052..647899 - 1848 WP_003024699.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T35776 WP_025799003.1 NZ_AP022486:643172-643549 [Citrobacter portucalensis]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T35776 NZ_AP022486:643172-643549 [Citrobacter portucalensis]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT35776 WP_072269511.1 NZ_AP022486:642796-643122 [Citrobacter portucalensis]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT35776 NZ_AP022486:642796-643122 [Citrobacter portucalensis]
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References