Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3493928..3494546 Replicon chromosome
Accession NZ_AP022482
Organism Escherichia coli strain STN0717-20

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JLE48_RS16790 Protein ID WP_001291435.1
Coordinates 3494328..3494546 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JLE48_RS16785 Protein ID WP_200931917.1
Coordinates 3493928..3494302 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLE48_RS16775 3489017..3490210 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JLE48_RS16780 3490233..3493382 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JLE48_RS16785 3493928..3494302 + 375 WP_200931917.1 Hha toxicity modulator TomB Antitoxin
JLE48_RS16790 3494328..3494546 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JLE48_RS16795 3494718..3495269 + 552 WP_000102568.1 maltose O-acetyltransferase -
JLE48_RS16800 3495385..3495855 + 471 WP_000136192.1 YlaC family protein -
JLE48_RS16805 3496019..3497569 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JLE48_RS16810 3497611..3497964 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JLE48_RS16820 3498343..3498654 + 312 WP_000409911.1 MGMT family protein -
JLE48_RS16825 3498685..3499257 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T35759 WP_001291435.1 NZ_AP022482:3494328-3494546 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T35759 NZ_AP022482:3494328-3494546 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14600.42 Da        Isoelectric Point: 4.9284

>AT35759 WP_200931917.1 NZ_AP022482:3493928-3494302 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDRQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT35759 NZ_AP022482:3493928-3494302 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCGTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References