Detailed information of TA system TA035747

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1798808..1799643
• Replicon: chromosome
• Accession: NZ_AP022482
• Organism: Escherichia coli strain STN0717-20

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A7I6H0K3
• Locus tag: JLE48_RS08525
• Protein ID: WP_000854760.1
• Coordinates: 1798808..1799185 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JLE48_RS08530
• Protein ID: WP_094321967.1
• Coordinates: 1799275..1799643 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLE48_RS08490	1794328..1794801	+	474	WP_001105407.1	DNA gyrase inhibitor SbmC	-
JLE48_RS08495	1794999..1796057	+	1059	WP_001200895.1	FUSC family protein	-
JLE48_RS08500	1796229..1796558	+	330	WP_000450409.1	DUF496 family protein	-
JLE48_RS08505	1796659..1796841	-	183	WP_024174802.1	ethanolamine utilization protein	-
JLE48_RS08510	1797295..1797684	-	390	WP_001445118.1	IS110 family transposase	-
JLE48_RS08515	1798482..1798595	-	114	WP_032140621.1	DUF957 domain-containing protein	-
JLE48_RS08520	1798608..1798811	-	204	WP_000761705.1	hypothetical protein	-
JLE48_RS08525	1798808..1799185	-	378	WP_000854760.1	TA system toxin CbtA family protein	Toxin
JLE48_RS08530	1799275..1799643	-	369	WP_094321967.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JLE48_RS08535	1799806..1800027	-	222	WP_000692345.1	DUF987 domain-containing protein	-
JLE48_RS08540	1800096..1800572	-	477	WP_001424026.1	RadC family protein	-
JLE48_RS08545	1800588..1801061	-	474	WP_001387789.1	antirestriction protein	-
JLE48_RS08550	1801403..1802164	-	762	Protein_1670	DUF945 domain-containing protein	-
JLE48_RS08555	1802358..1803899	+	1542	Protein_1671	IS21-like element ISEc12 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14165.19 Da
• Isoelectric Point: 7.3249

>T35747 WP_000854760.1 NZ_AP022482:c1799185-1798808 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Nucleotide

• Length: 378 bp

>T35747 NZ_AP022482:c1799185-1798808 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13604.45 Da
• Isoelectric Point: 6.6255

>AT35747 WP_094321967.1 NZ_AP022482:c1799643-1799275 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADILGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT35747 NZ_AP022482:c1799643-1799275 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACATCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A7I6H0K3