Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 9082..9752 Replicon plasmid pSTW0522-72-3
Accession NZ_AP022476
Organism Pseudomonas monteilii strain STW0522-72

Toxin (Protein)


Gene name vagD Uniprot ID Q2QCR9
Locus tag JLF49_RS27445 Protein ID WP_012477632.1
Coordinates 9315..9752 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q2QCS0
Locus tag JLF49_RS27440 Protein ID WP_012477631.1
Coordinates 9082..9318 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF49_RS27410 4322..4528 + 207 WP_015272391.1 zinc ribbon domain-containing protein -
JLF49_RS27415 4521..5138 + 618 WP_015272392.1 recombinase family protein -
JLF49_RS27420 5125..6261 + 1137 WP_015272393.1 replication initiator protein A -
JLF49_RS27425 7021..7179 - 159 WP_200929578.1 hypothetical protein -
JLF49_RS27430 7374..8024 + 651 WP_015272395.1 DNA-binding protein -
JLF49_RS27435 8647..9072 + 426 WP_015272397.1 DUF192 domain-containing protein -
JLF49_RS27440 9082..9318 + 237 WP_012477631.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JLF49_RS27445 9315..9752 + 438 WP_012477632.1 type II toxin-antitoxin system VapC family toxin Toxin
JLF49_RS27450 9759..9920 + 162 WP_015272398.1 hypothetical protein -
JLF49_RS27455 10048..10308 + 261 WP_015272399.1 hypothetical protein -
JLF49_RS27460 10989..11825 + 837 WP_015272400.1 DUF945 domain-containing protein -
JLF49_RS27465 11881..12309 + 429 WP_015272401.1 hypothetical protein -
JLF49_RS27470 12326..12829 + 504 WP_015272402.1 hypothetical protein -
JLF49_RS27475 12890..13240 + 351 WP_015272403.1 hypothetical protein -
JLF49_RS27480 13288..13500 + 213 WP_153334493.1 hypothetical protein -
JLF49_RS27485 14158..14412 + 255 WP_015272405.1 hypothetical protein -
JLF49_RS27490 14483..14659 + 177 WP_019692578.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaOXA-2 / blaIMP-11 / sul1 / qacE - 1..44219 44219
- inside Integron - - 69..43849 43780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15671.07 Da        Isoelectric Point: 8.5199

>T35709 WP_012477632.1 NZ_AP022476:9315-9752 [Pseudomonas monteilii]
MSKKTYMLDTNICSFIMRERPDAVLAKLEQAVTNQHRIVVSAITYSEMRFGAANPKASPKVAAMVDAFIQRLDAILSWDA
AAVDQTTQIRTALARLGTPIGNNDAAIAGHALAAGCVLVTNNTREFARVPGLVLEDWTQPAITKS

Download         Length: 438 bp

>T35709 NZ_AP022476:9315-9752 [Pseudomonas monteilii]
ATGAGCAAAAAGACGTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGCCCCGACGCGGTGCTGGCCAA
GCTGGAACAGGCAGTCACTAATCAGCACCGGATTGTCGTTTCGGCCATCACCTACTCCGAAATGCGTTTCGGGGCCGCCA
ACCCCAAGGCATCGCCCAAGGTTGCAGCGATGGTCGATGCCTTCATCCAGCGCCTGGACGCCATCCTGTCCTGGGACGCC
GCCGCCGTAGATCAAACAACGCAGATCCGCACCGCCCTCGCCCGCCTGGGTACGCCCATTGGCAACAACGATGCAGCGAT
AGCCGGCCATGCCCTGGCCGCTGGGTGTGTTCTGGTCACGAACAACACTCGCGAATTTGCTCGCGTTCCTGGCCTAGTCC
TTGAGGACTGGACCCAACCCGCCATTACCAAGAGTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9070.29 Da        Isoelectric Point: 4.4563

>AT35709 WP_012477631.1 NZ_AP022476:9082-9318 [Pseudomonas monteilii]
MRTVSIFMNSRNQAIRIPRDMEYQGVSELEIIRDGETLILRPVRPSWASLRDVAAADPDFLTERKDVIEEDRFLGDFT

Download         Length: 237 bp

>AT35709 NZ_AP022476:9082-9318 [Pseudomonas monteilii]
ATGCGTACCGTTTCCATTTTCATGAACAGCCGAAACCAGGCGATCCGCATCCCTCGGGATATGGAGTACCAGGGCGTTTC
CGAGCTGGAGATTATCCGCGACGGCGAAACGCTGATCCTGCGCCCTGTGCGCCCCTCCTGGGCATCGTTGCGCGACGTGG
CGGCCGCAGATCCTGACTTTCTGACCGAGCGAAAGGATGTGATCGAGGAAGACCGTTTCCTGGGTGACTTCACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A010RDD2

Antitoxin

Source ID Structure
AlphaFold DB A0A010SZE6

References