Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4692727..4693335 Replicon chromosome
Accession NZ_AP022473
Organism Pseudomonas monteilii strain STW0522-72

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag JLF49_RS22225 Protein ID WP_200928790.1
Coordinates 4693045..4693335 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A6G6V4Q8
Locus tag JLF49_RS22220 Protein ID WP_060499944.1
Coordinates 4692727..4693035 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF49_RS22195 4687898..4689760 - 1863 WP_060501849.1 protein translocase subunit SecD -
JLF49_RS22200 4689824..4690159 - 336 WP_008092587.1 preprotein translocase subunit YajC -
JLF49_RS22205 4690202..4691317 - 1116 WP_014589748.1 tRNA guanosine(34) transglycosylase Tgt -
JLF49_RS22210 4691332..4692381 - 1050 WP_104834019.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
JLF49_RS22220 4692727..4693035 - 309 WP_060499944.1 putative addiction module antidote protein Antitoxin
JLF49_RS22225 4693045..4693335 - 291 WP_200928790.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLF49_RS22230 4693447..4695969 - 2523 WP_200928791.1 TonB-dependent receptor -
JLF49_RS22235 4696045..4696986 - 942 WP_200928792.1 FecR domain-containing protein -
JLF49_RS22240 4696986..4697492 - 507 WP_060499947.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10711.19 Da        Isoelectric Point: 8.9632

>T35707 WP_200928790.1 NZ_AP022473:c4693335-4693045 [Pseudomonas monteilii]
VKTILTTDDFDAWFSKLSDKRSAMRIQARIDRAEAGNFGDCQAVGEGVSEMRIHYGPGYRVYFTQRGLEIVLLLAGGDKS
TQSKDIKTALDIARRL

Download         Length: 291 bp

>T35707 NZ_AP022473:c4693335-4693045 [Pseudomonas monteilii]
GTGAAGACCATCCTCACAACCGATGATTTCGATGCTTGGTTTTCCAAGCTTAGCGATAAGCGATCTGCGATGCGCATCCA
GGCGCGCATCGACCGTGCCGAAGCAGGGAATTTCGGTGATTGCCAAGCTGTGGGTGAGGGCGTCTCCGAGATGCGTATTC
ACTATGGGCCAGGATATCGTGTGTACTTCACCCAGCGCGGCCTTGAAATCGTGCTCCTGCTGGCGGGTGGCGATAAGTCC
ACTCAATCAAAAGACATCAAAACCGCCCTCGACATTGCACGACGGCTTTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10817.32 Da        Isoelectric Point: 6.2202

>AT35707 WP_060499944.1 NZ_AP022473:c4693035-4692727 [Pseudomonas monteilii]
MGNVKLKKWDSAEHLKTDEDMALYLEACIEEAGDDAAFIAKALGTIARAKGMAQLARDTGLGRESLYKALSGEGNPSFAT
ILKVTRALGLQLHADVASTHTG

Download         Length: 309 bp

>AT35707 NZ_AP022473:c4693035-4692727 [Pseudomonas monteilii]
ATGGGTAACGTCAAGTTGAAAAAATGGGACAGTGCCGAACACCTCAAGACGGACGAGGACATGGCGCTTTACCTCGAAGC
TTGCATTGAAGAGGCGGGTGATGATGCGGCTTTTATCGCCAAGGCGCTCGGCACCATTGCGCGTGCAAAAGGCATGGCTC
AGTTGGCCCGTGATACCGGGCTTGGGCGTGAAAGCCTGTACAAGGCGTTGTCCGGCGAGGGGAACCCAAGCTTCGCCACC
ATCCTGAAGGTGACCAGAGCGCTTGGCCTACAGCTTCATGCTGACGTTGCATCCACTCATACTGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6V4Q8

References