35703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3725634..3726301 Replicon chromosome
Accession NZ_AP022465
Organism Enterobacter roggenkampii strain STW0522-66

Toxin (Protein)


Gene name ypjF Uniprot ID A0A156PNF2
Locus tag JLF42_RS17870 Protein ID WP_001618791.1
Coordinates 3725972..3726301 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A156PNH9
Locus tag JLF42_RS17865 Protein ID WP_001618790.1
Coordinates 3725634..3725951 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF42_RS17820 3721072..3721893 + 822 WP_001548153.1 DUF945 domain-containing protein -
JLF42_RS17825 3722110..3722811 + 702 WP_001581462.1 WYL domain-containing protein -
JLF42_RS17830 3722852..3723088 + 237 WP_032181217.1 hypothetical protein -
JLF42_RS17835 3723088..3723531 + 444 WP_001547764.1 phage transcriptional regulator -
JLF42_RS17840 3723554..3724021 + 468 WP_001547765.1 hypothetical protein -
JLF42_RS17845 3724098..3724337 + 240 WP_000194654.1 DUF905 domain-containing protein -
JLF42_RS17850 3724435..3724893 + 459 WP_000211838.1 antirestriction protein -
JLF42_RS17855 3724909..3725385 + 477 WP_000811693.1 RadC family protein -
JLF42_RS17860 3725394..3725615 + 222 WP_044864853.1 DUF987 domain-containing protein -
JLF42_RS17865 3725634..3725951 + 318 WP_001618790.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLF42_RS17870 3725972..3726301 + 330 WP_001618791.1 TA system toxin CbtA family protein Toxin
JLF42_RS17875 3726584..3727345 + 762 WP_021241992.1 hypothetical protein -
JLF42_RS17885 3728759..3729340 + 582 WP_021241990.1 recombinase family protein -
JLF42_RS17890 3729337..3730002 + 666 WP_021241989.1 hypothetical protein -
JLF42_RS17895 3730298..3730483 - 186 WP_127341472.1 hypothetical protein -
JLF42_RS17900 3730492..3730695 - 204 WP_127341473.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3666230..3762981 96751


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12509.43 Da        Isoelectric Point: 7.2767

>T35703 WP_001618791.1 NZ_AP022465:3725972-3726301 [Enterobacter roggenkampii]
MNTLPATTQRAAKPCLSPVAVWKMLLTHLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADTVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTDLLKTNVK

Download         Length: 330 bp

>T35703 NZ_AP022465:3725972-3726301 [Enterobacter roggenkampii]
ATGAATACTTTACCTGCAACAACCCAGCGGGCGGCGAAACCCTGCCTGTCACCCGTGGCTGTCTGGAAAATGCTACTGAC
ACACCTGCTGGAACAACACTATGGTCTGACCCTCAACGACACACCGTTCAGTGAGGAACGAGTTATACAGGAACATATCG
ATGCTGGTATCACGCTGGCTGATACTGTGAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAGACTCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGACTTGCTAAAAACTAA
CGTGAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11905.54 Da        Isoelectric Point: 7.3234

>AT35703 WP_001618790.1 NZ_AP022465:3725634-3725951 [Enterobacter roggenkampii]
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDAECRKLDETFPHFIRQMESMLTTGEVSPQHAHCVILYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT35703 NZ_AP022465:3725634-3725951 [Enterobacter roggenkampii]
ATGAGCAATATCACATGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTACCTGGCTGACCGGGCCAGCATCACCGGTAGATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAAGTCAGCCCCCAACATGCCCACTGCGTCATCCTGTACCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A156PNF2

Antitoxin

Source ID Structure
AlphaFold DB A0A156PNH9

References