Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 542191..542707 Replicon chromosome
Accession NZ_AP022465
Organism Enterobacter roggenkampii strain STW0522-66

Toxin (Protein)


Gene name relE Uniprot ID A0A0W2HDR3
Locus tag JLF42_RS02595 Protein ID WP_008501399.1
Coordinates 542423..542707 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag JLF42_RS02590 Protein ID WP_008501400.1
Coordinates 542191..542433 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF42_RS02575 538281..539021 + 741 WP_008501404.1 KDGP aldolase family protein -
JLF42_RS02580 539047..540183 + 1137 WP_055322102.1 lactonase family protein -
JLF42_RS02585 540203..542113 + 1911 WP_055322101.1 BglG family transcription antiterminator -
JLF42_RS02590 542191..542433 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JLF42_RS02595 542423..542707 + 285 WP_008501399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLF42_RS02600 542711..543175 - 465 WP_023326577.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JLF42_RS02605 543281..545419 - 2139 WP_023293422.1 anaerobic ribonucleoside-triphosphate reductase -
JLF42_RS02610 545789..546361 - 573 WP_032655196.1 fructose PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10768.53 Da        Isoelectric Point: 10.3039

>T35689 WP_008501399.1 NZ_AP022465:542423-542707 [Enterobacter roggenkampii]
MTYELEFDPRALKEWSKLGDTVKNQFKKKLAGVLANPRVESARLHNLPDCYKIKLKASGYRLVYQVQDSVITVFVIAVGK
REKSAAYHDANKRL

Download         Length: 285 bp

>T35689 NZ_AP022465:542423-542707 [Enterobacter roggenkampii]
ATGACTTATGAACTGGAATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGGATACGGTCAAAAACCAGTTTAA
GAAGAAACTTGCCGGGGTATTGGCAAATCCCCGGGTCGAATCGGCCCGCCTGCATAATCTGCCTGATTGCTACAAAATCA
AACTCAAGGCGTCTGGCTATCGCCTGGTTTATCAGGTTCAGGACAGCGTTATAACGGTATTTGTTATCGCCGTTGGGAAA
AGAGAGAAATCAGCCGCTTATCACGACGCAAATAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT35689 WP_008501400.1 NZ_AP022465:542191-542433 [Enterobacter roggenkampii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT35689 NZ_AP022465:542191-542433 [Enterobacter roggenkampii]
ATGGCCACGCTAAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCGGTGCGATTGCTGTTTCAGTACGTTGCTGAAACGGGGCGCATGCCGGTGAAAACGGTCACGATCAGCGACA
GCGAAGATGCGCTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATAAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W2HDR3

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References