35685

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 4286693..4287372 Replicon chromosome
Accession NZ_AP022452
Organism Enterobacter kobei strain STW0522-62

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag JLF39_RS20745 Protein ID WP_200924562.1
Coordinates 4286693..4287034 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID -
Locus tag JLF39_RS20750 Protein ID WP_200924563.1
Coordinates 4287055..4287372 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF39_RS20695 4281907..4282140 - 234 WP_014884920.1 DUF2732 domain-containing protein -
JLF39_RS20700 4282244..4282393 - 150 WP_017382390.1 DUF3927 family protein -
JLF39_RS20705 4282393..4282818 - 426 WP_058651063.1 tellurite resistance TerB family protein -
JLF39_RS20710 4282888..4283088 - 201 WP_017382392.1 hypothetical protein -
JLF39_RS20715 4283078..4283302 - 225 WP_017441498.1 DUF2724 domain-containing protein -
JLF39_RS20720 4283310..4283819 - 510 WP_062856345.1 phage regulatory CII family protein -
JLF39_RS20725 4283854..4284090 - 237 WP_063147870.1 hypothetical protein -
JLF39_RS20730 4284191..4284814 + 624 WP_077266489.1 phage repressor protein CI -
JLF39_RS20735 4284818..4285357 + 540 WP_200924561.1 hypothetical protein -
JLF39_RS20740 4285360..4286445 + 1086 WP_063160408.1 tyrosine-type recombinase/integrase -
JLF39_RS20745 4286693..4287034 - 342 WP_200924562.1 TA system toxin CbtA family protein Toxin
JLF39_RS20750 4287055..4287372 - 318 WP_200924563.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLF39_RS20755 4287391..4287612 - 222 WP_000691994.1 DUF987 domain-containing protein -
JLF39_RS20760 4287621..4288097 - 477 WP_000811693.1 RadC family protein -
JLF39_RS20765 4288113..4288571 - 459 WP_063199995.1 antirestriction protein -
JLF39_RS20770 4288673..4288912 - 240 WP_063199992.1 DUF905 domain-containing protein -
JLF39_RS20775 4288989..4289456 - 468 WP_200924564.1 hypothetical protein -
JLF39_RS20780 4289479..4289922 - 444 WP_181220862.1 hypothetical protein -
JLF39_RS20785 4289922..4290158 - 237 WP_001144031.1 hypothetical protein -
JLF39_RS20790 4290199..4290900 - 702 WP_023326104.1 WYL domain-containing protein -
JLF39_RS20795 4291117..4291938 - 822 WP_200924565.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4248414..4288571 40157


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13005.07 Da        Isoelectric Point: 10.4476

>T35685 WP_200924562.1 NZ_AP022452:c4287034-4286693 [Enterobacter kobei]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAADILRARQATGLLRQSRKNSVR

Download         Length: 342 bp

>T35685 NZ_AP022452:c4287034-4286693 [Enterobacter kobei]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
CCGCCTGCTGAAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGAATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGCAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11970.56 Da        Isoelectric Point: 7.0267

>AT35685 WP_200924563.1 NZ_AP022452:c4287372-4287055 [Enterobacter kobei]
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT35685 NZ_AP022452:c4287372-4287055 [Enterobacter kobei]
ATGAGCAACATTACATGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTATCTGGCTGACCGGGCCAGCATCACCGGCAGGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References