Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3997002..3997659 Replicon chromosome
Accession NZ_AP022452
Organism Enterobacter kobei strain STW0522-62

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag JLF39_RS19255 Protein ID WP_014885136.1
Coordinates 3997002..3997412 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag JLF39_RS19260 Protein ID WP_010435322.1
Coordinates 3997393..3997659 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF39_RS19235 3992996..3994729 - 1734 WP_200924521.1 single-stranded-DNA-specific exonuclease RecJ -
JLF39_RS19240 3994735..3995448 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLF39_RS19245 3995477..3996373 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
JLF39_RS19250 3996475..3996996 + 522 WP_200924522.1 flavodoxin FldB -
JLF39_RS19255 3997002..3997412 - 411 WP_014885136.1 protein YgfX Toxin
JLF39_RS19260 3997393..3997659 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
JLF39_RS19265 3997954..3998934 + 981 WP_200924523.1 tRNA-modifying protein YgfZ -
JLF39_RS19270 3999019..3999678 - 660 WP_023331242.1 hemolysin III family protein -
JLF39_RS19275 3999944..4000675 + 732 WP_058689873.1 MurR/RpiR family transcriptional regulator -
JLF39_RS19280 4000792..4002225 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T35683 WP_014885136.1 NZ_AP022452:c3997412-3997002 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T35683 NZ_AP022452:c3997412-3997002 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTGAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT35683 WP_010435322.1 NZ_AP022452:c3997659-3997393 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT35683 NZ_AP022452:c3997659-3997393 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References