Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4089831..4090488 Replicon chromosome
Accession NZ_AP022446
Organism Enterobacter kobei strain STW0522-60

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag JLF31_RS19980 Protein ID WP_014885136.1
Coordinates 4089831..4090241 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag JLF31_RS19985 Protein ID WP_010435322.1
Coordinates 4090222..4090488 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF31_RS19960 4085825..4087558 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
JLF31_RS19965 4087564..4088277 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLF31_RS19970 4088306..4089202 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
JLF31_RS19975 4089304..4089825 + 522 WP_014885135.1 flavodoxin FldB -
JLF31_RS19980 4089831..4090241 - 411 WP_014885136.1 protein YgfX Toxin
JLF31_RS19985 4090222..4090488 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
JLF31_RS19990 4090783..4091763 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
JLF31_RS19995 4091848..4092507 - 660 WP_023331242.1 hemolysin III family protein -
JLF31_RS20000 4092773..4093504 + 732 WP_058689873.1 MurR/RpiR family transcriptional regulator -
JLF31_RS20005 4093621..4095054 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T35666 WP_014885136.1 NZ_AP022446:c4090241-4089831 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T35666 NZ_AP022446:c4090241-4089831 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTATTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT35666 WP_010435322.1 NZ_AP022446:c4090488-4090222 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT35666 NZ_AP022446:c4090488-4090222 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References