Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 80625..81265 Replicon plasmid pSTW0522-51-1
Accession NZ_AP022432
Organism Enterobacter kobei strain STW0522-51

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JLF35_RS22865 Protein ID WP_057688291.1
Coordinates 80852..81265 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag JLF35_RS22860 Protein ID WP_057688290.1
Coordinates 80625..80855 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF35_RS22830 76587..77213 + 627 WP_008502208.1 ParA family plasmid-partitioning AAA ATPase -
JLF35_RS22835 77210..77515 + 306 WP_071530977.1 hypothetical protein -
JLF35_RS22840 77696..78469 - 774 WP_008502207.1 site-specific integrase -
JLF35_RS22845 78469..79289 - 821 Protein_82 hypothetical protein -
JLF35_RS22850 79338..79667 - 330 WP_114191457.1 hypothetical protein -
JLF35_RS22855 79717..80019 - 303 WP_008502204.1 hypothetical protein -
JLF35_RS22860 80625..80855 + 231 WP_057688290.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JLF35_RS22865 80852..81265 + 414 WP_057688291.1 type II toxin-antitoxin system VapC family toxin Toxin
JLF35_RS22870 81683..83944 - 2262 WP_200923474.1 NACHT domain-containing protein -
JLF35_RS22875 84039..84395 - 357 WP_200923475.1 hypothetical protein -
JLF35_RS22880 84375..85343 + 969 WP_165356696.1 IS5-like element IS903B family transposase -
JLF35_RS22885 85595..85969 - 375 WP_013096889.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-10 - 1..159829 159829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15243.79 Da        Isoelectric Point: 7.7815

>T35649 WP_057688291.1 NZ_AP022432:80852-81265 [Enterobacter kobei]
MNKIYMLDTCICSFIMREQPEAVRKRLAQAVLRGHRIVISAITYQEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTEIRVALRMAGMPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPDLKLEDWV

Download         Length: 414 bp

>T35649 NZ_AP022432:80852-81265 [Enterobacter kobei]
ATGAACAAGATTTATATGCTGGACACCTGTATCTGCTCGTTCATCATGCGAGAGCAGCCGGAAGCCGTCCGGAAACGCCT
GGCACAGGCGGTGCTGCGCGGTCACCGCATTGTGATCTCGGCCATCACCTACCAGGAGATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCACCCCGCCACGTGCAGCTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGATGCGACCACGGAGATTAGGGTGGCGCTGCGCATGGCCGGCATGCCGATCGGCCCGAACGACACGGCAATAGC
CGGGCATGCCATTGCCGCCGGCGCGGTGCTGGTGACGAACAATGTGAGAGAGTTTGAGCGGGTACCTGACCTGAAGCTGG
AAGACTGGGTATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8900.96 Da        Isoelectric Point: 4.2188

>AT35649 WP_057688290.1 NZ_AP022432:80625-80855 [Enterobacter kobei]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWDSFFELERADPDFMAEREDVVTDEGRFDL

Download         Length: 231 bp

>AT35649 NZ_AP022432:80625-80855 [Enterobacter kobei]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCGACCTGGGATTCATTCTTTGAGCTCG
AAAGAGCCGATCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References