Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3810404..3811061 Replicon chromosome
Accession NZ_AP022431
Organism Enterobacter kobei strain STW0522-51

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag JLF35_RS18095 Protein ID WP_014885136.1
Coordinates 3810404..3810814 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag JLF35_RS18100 Protein ID WP_010435322.1
Coordinates 3810795..3811061 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF35_RS18075 3806398..3808131 - 1734 WP_032635612.1 single-stranded-DNA-specific exonuclease RecJ -
JLF35_RS18080 3808137..3808850 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLF35_RS18085 3808879..3809775 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
JLF35_RS18090 3809877..3810398 + 522 WP_071922917.1 flavodoxin FldB -
JLF35_RS18095 3810404..3810814 - 411 WP_014885136.1 protein YgfX Toxin
JLF35_RS18100 3810795..3811061 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
JLF35_RS18105 3811356..3812336 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
JLF35_RS18110 3812421..3813080 - 660 WP_023331242.1 hemolysin III family protein -
JLF35_RS18115 3813346..3814077 + 732 WP_200923469.1 MurR/RpiR family transcriptional regulator -
JLF35_RS18120 3814194..3815627 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T35647 WP_014885136.1 NZ_AP022431:c3810814-3810404 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T35647 NZ_AP022431:c3810814-3810404 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACGCCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGCATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCCTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT35647 WP_010435322.1 NZ_AP022431:c3811061-3810795 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT35647 NZ_AP022431:c3811061-3810795 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References