Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 127963..128699 Replicon plasmid pSTW0522-39-1
Accession NZ_AP022413
Organism Klebsiella quasipneumoniae strain STW0522-39

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag JLF46_RS27115 Protein ID WP_004098919.1
Coordinates 128217..128699 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A455TK27
Locus tag JLF46_RS27110 Protein ID WP_020804426.1
Coordinates 127963..128229 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF46_RS27065 124097..124531 + 435 WP_048293723.1 hypothetical protein -
JLF46_RS27070 124910..125008 - 99 WP_004118688.1 type II toxin-antitoxin system RelE/ParE family toxin -
JLF46_RS27075 124995..125174 - 180 WP_004118349.1 type II toxin-antitoxin system ParD family antitoxin -
JLF46_RS27080 125488..125751 + 264 WP_004118691.1 hypothetical protein -
JLF46_RS27085 125748..126362 + 615 WP_200928087.1 hypothetical protein -
JLF46_RS27090 126393..126887 + 495 WP_016528789.1 hypothetical protein -
JLF46_RS27095 126948..127151 + 204 WP_004150739.1 hemolysin expression modulator Hha -
JLF46_RS27100 127200..127457 + 258 WP_004098928.1 hypothetical protein -
JLF46_RS27105 127533..127787 + 255 WP_032425571.1 hypothetical protein -
JLF46_RS27110 127963..128229 + 267 WP_020804426.1 DUF1778 domain-containing protein Antitoxin
JLF46_RS27115 128217..128699 + 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
JLF46_RS27120 128900..130303 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
JLF46_RS27125 130332..130964 - 633 WP_001567369.1 hypothetical protein -
JLF46_RS27130 131190..132536 + 1347 WP_077259381.1 ISNCY family transposase -
JLF46_RS27135 132585..132980 + 396 WP_021312679.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA 1..172805 172805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T35634 WP_004098919.1 NZ_AP022413:128217-128699 [Klebsiella quasipneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T35634 NZ_AP022413:128217-128699 [Klebsiella quasipneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGTGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10124.47 Da        Isoelectric Point: 4.3108

>AT35634 WP_020804426.1 NZ_AP022413:127963-128229 [Klebsiella quasipneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINELL
ARKPQWDV

Download         Length: 267 bp

>AT35634 NZ_AP022413:127963-128229 [Klebsiella quasipneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCCCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATGAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A455TK27

References