Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 841337..841994 Replicon chromosome
Accession NZ_AP022412
Organism Klebsiella quasipneumoniae strain STW0522-39

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag JLF46_RS04215 Protein ID WP_004205323.1
Coordinates 841584..841994 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JLF46_RS04210 Protein ID WP_002916312.1
Coordinates 841337..841603 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF46_RS04185 836494..837927 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
JLF46_RS04190 838046..838774 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
JLF46_RS04195 838824..839135 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
JLF46_RS04200 839298..839957 + 660 WP_004205319.1 hemolysin III family protein -
JLF46_RS04205 840108..841091 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
JLF46_RS04210 841337..841603 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JLF46_RS04215 841584..841994 + 411 WP_004205323.1 protein YgfX Toxin
JLF46_RS04220 842001..842522 - 522 WP_004205324.1 flavodoxin FldB -
JLF46_RS04225 842623..843519 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JLF46_RS04230 843542..844255 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLF46_RS04235 844261..845994 + 1734 WP_064150860.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T35621 WP_004205323.1 NZ_AP022412:841584-841994 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T35621 NZ_AP022412:841584-841994 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT35621 WP_002916312.1 NZ_AP022412:841337-841603 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT35621 NZ_AP022412:841337-841603 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References