Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 676682..677435 Replicon chromosome
Accession NZ_AP022412
Organism Klebsiella quasipneumoniae strain STW0522-39

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag JLF46_RS03340 Protein ID WP_025799003.1
Coordinates 677058..677435 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag JLF46_RS03335 Protein ID WP_072269511.1
Coordinates 676682..677008 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF46_RS03315 672090..675245 + 3156 WP_077267777.1 AIDA repeat-containing protein -
JLF46_RS03320 675468..675899 + 432 WP_088903392.1 antirestriction protein -
JLF46_RS03325 675911..676390 + 480 WP_025798999.1 DNA repair protein RadC -
JLF46_RS03330 676404..676625 + 222 WP_045888217.1 DUF987 domain-containing protein -
JLF46_RS03335 676682..677008 + 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLF46_RS03340 677058..677435 + 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
JLF46_RS03345 677432..677923 + 492 WP_045888216.1 hypothetical protein -
JLF46_RS03350 677952..678155 + 204 WP_025799007.1 DUF957 domain-containing protein -
JLF46_RS03355 678237..679082 + 846 WP_049016442.1 DUF4942 domain-containing protein -
JLF46_RS03365 679385..679891 + 507 WP_004205266.1 G/U mismatch-specific DNA glycosylase -
JLF46_RS03370 679991..681832 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T35620 WP_025799003.1 NZ_AP022412:677058-677435 [Klebsiella quasipneumoniae]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T35620 NZ_AP022412:677058-677435 [Klebsiella quasipneumoniae]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT35620 WP_072269511.1 NZ_AP022412:676682-677008 [Klebsiella quasipneumoniae]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT35620 NZ_AP022412:676682-677008 [Klebsiella quasipneumoniae]
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References