35589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3930237..3930943 Replicon chromosome
Accession NZ_AP022399
Organism Citrobacter portucalensis strain STW0522-30

Toxin (Protein)


Gene name ykfI Uniprot ID A0A7I6XM57
Locus tag JLF43_RS18855 Protein ID WP_060659174.1
Coordinates 3930237..3930605 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A7I6XGP2
Locus tag JLF43_RS18860 Protein ID WP_060659175.1
Coordinates 3930626..3930943 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF43_RS18835 3925410..3925859 + 450 WP_174785083.1 GNAT family N-acetyltransferase -
JLF43_RS18840 3926027..3927031 + 1005 WP_200920758.1 LacI family DNA-binding transcriptional regulator -
JLF43_RS18845 3927185..3928636 + 1452 WP_008783827.1 Na+/H+ antiporter NhaC -
JLF43_RS18850 3928649..3929830 + 1182 WP_003830857.1 pyridoxal phosphate-dependent aminotransferase -
JLF43_RS18855 3930237..3930605 - 369 WP_060659174.1 TA system toxin CbtA family protein Toxin
JLF43_RS18860 3930626..3930943 - 318 WP_060659175.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLF43_RS18865 3930963..3931184 - 222 WP_047738075.1 DUF987 domain-containing protein -
JLF43_RS18870 3931193..3931675 - 483 WP_060659176.1 DNA repair protein RadC -
JLF43_RS18875 3931684..3932148 - 465 WP_114681874.1 antirestriction protein -
JLF43_RS18880 3932289..3935132 - 2844 WP_115626798.1 Ag43/Cah family autotransporter adhesin -
JLF43_RS18885 3935205..3935891 - 687 WP_047738081.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13861.00 Da        Isoelectric Point: 7.7001

>T35589 WP_060659174.1 NZ_AP022399:c3930605-3930237 [Citrobacter portucalensis]
MKFQPAKNMRAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRSGF
SSQEQAPYLTVTDILHARKACGLMNSCSYREVSNIVLSRSRQ

Download         Length: 369 bp

>T35589 NZ_AP022399:c3930605-3930237 [Citrobacter portucalensis]
ATGAAATTTCAACCTGCAAAAAATATGCGGGCGGCGAAGCCATGCCTATCGCCCGTGACTATCTGGCAAATGTTACTTAG
TCGTCTGCTGGAACAGCATTATGGCCTGACGCTAAACGATACACCTTTCTGTGATGAAACCGTCATACAGGAACATATCG
ATGCCGGTATCACCCTGGCTAATGCTATCAACTTTCTGGTGGAGAAGTATGAGTTAGTCCGTATCGATCGCAGTGGATTT
TCCTCACAGGAACAAGCGCCATATCTGACCGTGACAGATATCCTTCATGCCAGGAAAGCATGCGGATTAATGAACAGTTG
TTCTTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGTCAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11893.33 Da        Isoelectric Point: 6.3164

>AT35589 WP_060659175.1 NZ_AP022399:c3930943-3930626 [Citrobacter portucalensis]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASNTGQFSDAECRKLDETFPHFISQMELMLTSGELNPRHAHSVTLYH
DGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT35589 NZ_AP022399:c3930943-3930626 [Citrobacter portucalensis]
ATGAGTAACATCACATGGGGCCTGCAGCGGGATATCACGCCGCGCCTGGGAGCCCGCCTTGTGCAAGAAGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCAACACCGGTCAATTCAGTGACGCCGAATGCCGGAAACTGGATGAAACTTTCCCGC
ACTTTATCAGCCAGATGGAATTGATGCTGACCTCCGGTGAACTGAATCCTCGTCATGCCCACAGCGTCACCCTGTACCAC
GACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGCTGCGGCTACGTATACATCGCCGTTTATCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6XM57

Antitoxin

Source ID Structure
AlphaFold DB A0A7I6XGP2

References