35588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3737872..3738492 Replicon chromosome
Accession NZ_AP022399
Organism Citrobacter portucalensis strain STW0522-30

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JLF43_RS17955 Protein ID WP_002892050.1
Coordinates 3738274..3738492 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag JLF43_RS17950 Protein ID WP_003021733.1
Coordinates 3737872..3738246 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF43_RS17940 3733018..3734211 + 1194 WP_003831044.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JLF43_RS17945 3734234..3737383 + 3150 WP_193135115.1 efflux RND transporter permease AcrB -
JLF43_RS17950 3737872..3738246 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
JLF43_RS17955 3738274..3738492 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JLF43_RS17960 3738674..3739225 + 552 WP_003835924.1 maltose O-acetyltransferase -
JLF43_RS17965 3739342..3739812 + 471 WP_003021724.1 YlaC family protein -
JLF43_RS17970 3739891..3740031 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
JLF43_RS17975 3740033..3740293 - 261 WP_008783961.1 type B 50S ribosomal protein L31 -
JLF43_RS17980 3740482..3742035 + 1554 WP_200920716.1 EAL domain-containing protein -
JLF43_RS17985 3742087..3742440 - 354 WP_003831033.1 DUF1428 family protein -
JLF43_RS17990 3742505..3743134 - 630 WP_003831032.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T35588 WP_002892050.1 NZ_AP022399:3738274-3738492 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T35588 NZ_AP022399:3738274-3738492 [Citrobacter portucalensis]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT35588 WP_003021733.1 NZ_AP022399:3737872-3738246 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT35588 NZ_AP022399:3737872-3738246 [Citrobacter portucalensis]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTTAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References