Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 700922..701675 Replicon chromosome
Accession NZ_AP022389
Organism Citrobacter portucalensis strain STW0522-26

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag JLF45_RS03370 Protein ID WP_025799003.1
Coordinates 701298..701675 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag JLF45_RS03365 Protein ID WP_072269511.1
Coordinates 700922..701248 (+) Length 109 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF45_RS03345 696330..699485 + 3156 WP_077267777.1 AIDA repeat-containing protein -
JLF45_RS03350 699708..700139 + 432 WP_088903392.1 antirestriction protein -
JLF45_RS03355 700151..700630 + 480 WP_025798999.1 DNA repair protein RadC -
JLF45_RS03360 700644..700865 + 222 WP_045888217.1 DUF987 domain-containing protein -
JLF45_RS03365 700922..701248 + 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLF45_RS03370 701298..701675 + 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
JLF45_RS03375 701672..702163 + 492 WP_045888216.1 hypothetical protein -
JLF45_RS03380 702192..702395 + 204 WP_025799007.1 DUF957 domain-containing protein -
JLF45_RS03385 702477..703322 + 846 WP_025799009.1 DUF4942 domain-containing protein -
JLF45_RS03395 703626..704132 + 507 WP_149281949.1 G/U mismatch-specific DNA glycosylase -
JLF45_RS03400 704178..706025 - 1848 WP_003024699.1 RNA polymerase sigma factor RpoD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(4-103)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T35537 WP_025799003.1 NZ_AP022389:701298-701675 [Citrobacter portucalensis]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T35537 NZ_AP022389:701298-701675 [Citrobacter portucalensis]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT35537 WP_072269511.1 NZ_AP022389:700922-701248 [Citrobacter portucalensis]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT35537 NZ_AP022389:700922-701248 [Citrobacter portucalensis]
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A097QYR4


Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References