Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 700922..701675 | Replicon | chromosome |
Accession | NZ_AP022389 | ||
Organism | Citrobacter portucalensis strain STW0522-26 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A097QYR4 |
Locus tag | JLF45_RS03370 | Protein ID | WP_025799003.1 |
Coordinates | 701298..701675 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A7T0E0C6 |
Locus tag | JLF45_RS03365 | Protein ID | WP_072269511.1 |
Coordinates | 700922..701248 (+) | Length | 109 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JLF45_RS03345 | 696330..699485 | + | 3156 | WP_077267777.1 | AIDA repeat-containing protein | - |
JLF45_RS03350 | 699708..700139 | + | 432 | WP_088903392.1 | antirestriction protein | - |
JLF45_RS03355 | 700151..700630 | + | 480 | WP_025798999.1 | DNA repair protein RadC | - |
JLF45_RS03360 | 700644..700865 | + | 222 | WP_045888217.1 | DUF987 domain-containing protein | - |
JLF45_RS03365 | 700922..701248 | + | 327 | WP_072269511.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
JLF45_RS03370 | 701298..701675 | + | 378 | WP_025799003.1 | TA system toxin CbtA family protein | Toxin |
JLF45_RS03375 | 701672..702163 | + | 492 | WP_045888216.1 | hypothetical protein | - |
JLF45_RS03380 | 702192..702395 | + | 204 | WP_025799007.1 | DUF957 domain-containing protein | - |
JLF45_RS03385 | 702477..703322 | + | 846 | WP_025799009.1 | DUF4942 domain-containing protein | - |
JLF45_RS03395 | 703626..704132 | + | 507 | WP_149281949.1 | G/U mismatch-specific DNA glycosylase | - |
JLF45_RS03400 | 704178..706025 | - | 1848 | WP_003024699.1 | RNA polymerase sigma factor RpoD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13993.97 Da Isoelectric Point: 6.8515
>T35537 WP_025799003.1 NZ_AP022389:701298-701675 [Citrobacter portucalensis]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR
Download Length: 378 bp
>T35537 NZ_AP022389:701298-701675 [Citrobacter portucalensis]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12016.71 Da Isoelectric Point: 6.4674
>AT35537 WP_072269511.1 NZ_AP022389:700922-701248 [Citrobacter portucalensis]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE
Download Length: 327 bp
>AT35537 NZ_AP022389:700922-701248 [Citrobacter portucalensis]
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A097QYR4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7T0E0C6 |