Detailed information of TA system TA035536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 38395..38961
• Replicon: chromosome
• Accession: NZ_AP022389
• Organism: Citrobacter portucalensis strain STW0522-26

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JLF45_RS00185
• Protein ID: WP_200920966.1
• Coordinates: 38395..38697 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7I6X5E4
• Locus tag: JLF45_RS00190
• Protein ID: WP_008786497.1
• Coordinates: 38701..38961 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLF45_RS00170	34047..36827	+	2781	WP_200920964.1	intestinal colonization autotransporter adhesin MisL	-
JLF45_RS00175	36920..37252	-	333	WP_003827189.1	DUF1493 family protein	-
JLF45_RS00180	37700..38185	-	486	WP_200920965.1	type VI secretion system tube protein Hcp	-
JLF45_RS00185	38395..38697	-	303	WP_200920966.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JLF45_RS00190	38701..38961	-	261	WP_008786497.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JLF45_RS00195	39136..39426	-	291	WP_197385420.1	SymE family type I addiction module toxin	-
JLF45_RS00200	39563..39757	+	195	WP_003827195.1	toxin-antitoxin system HicB family antitoxin	-
JLF45_RS00205	39766..40322	-	557	Protein_40	hypothetical protein	-
JLF45_RS00215	40816..42198	+	1383	WP_200920967.1	glycoside-pentoside-hexuronide family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11621.25 Da
• Isoelectric Point: 8.0883

>T35536 WP_200920966.1 NZ_AP022389:c38697-38395 [Citrobacter portucalensis]
VSYKLTGEAQHDIIEIRDYTSRNWGAKQSKDYLRKLQVVLSQLAEMPGMGHHRINDFCEDIYSFPYVSHMIYYSAQDTNI
VVLAVLHQSRVPTKHLGQRL

Nucleotide

• Length: 303 bp

>T35536 NZ_AP022389:c38697-38395 [Citrobacter portucalensis]
GTGAGTTACAAACTTACTGGAGAAGCACAGCACGATATTATTGAAATCCGTGATTACACATCAAGAAATTGGGGCGCTAA
ACAGTCCAAGGATTATCTTAGAAAATTACAGGTCGTTCTCTCTCAGTTAGCTGAAATGCCAGGCATGGGTCATCATCGAA
TTAATGATTTTTGTGAAGATATTTACAGCTTTCCTTATGTTAGCCATATGATTTACTACAGTGCACAAGACACAAATATT
GTTGTACTGGCAGTCTTACACCAAAGCCGAGTACCAACAAAACATCTGGGACAACGTTTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9736.15 Da
• Isoelectric Point: 5.5882

>AT35536 WP_008786497.1 NZ_AP022389:c38961-38701 [Citrobacter portucalensis]
MHTLTANEAKTQFGDMLLKAQREPVQINRNGKPVAVVVSIEDYEQMEAMKLQLLKAKIQRAQNDIHLGNIVDGDAFFDEL
MDQHKG

Nucleotide

• Length: 261 bp

>AT35536 NZ_AP022389:c38961-38701 [Citrobacter portucalensis]
ATGCATACTCTTACGGCAAATGAAGCCAAAACCCAGTTTGGCGATATGCTACTTAAAGCGCAGCGAGAGCCAGTGCAAAT
TAACCGTAACGGTAAGCCTGTTGCAGTTGTTGTTTCCATTGAAGACTATGAACAAATGGAAGCCATGAAGCTCCAGTTAC
TGAAGGCCAAAATTCAGCGTGCTCAAAACGATATTCATTTGGGCAATATTGTTGATGGTGATGCTTTTTTTGATGAGTTG
ATGGATCAACACAAAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A7I6X5E4