Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1254213..1255066 Replicon chromosome
Accession NZ_AP022379
Organism Bifidobacterium longum subsp. longum strain JCM 7052

Toxin (Protein)


Gene name relE Uniprot ID V6XWY1
Locus tag BLGA_RS05405 Protein ID WP_007054468.1
Coordinates 1254213..1254704 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6XX41
Locus tag BLGA_RS05410 Protein ID WP_008783109.1
Coordinates 1254704..1255066 (-) Length 121 a.a.

Genomic Context

BLGA_RS05385BLGA_RS05390BLGA_RS05395BLGA_RS05400BLGA_RS05405BLGA_RS05410BLGA_RS05415
Location: 1249283..1250515 (1233 bp)
Type: Others
Protein ID: WP_007056207.1
Location: 1250550..1251275 (726 bp)
Type: Others
Protein ID: WP_007056206.1
Location: 1251315..1251956 (642 bp)
Type: Others
Protein ID: WP_007052627.1
Location: 1252046..1254151 (2106 bp)
Type: Others
Protein ID: WP_007052626.1
Location: 1254213..1254704 (492 bp)
Type: Toxin
Protein ID: WP_007054468.1
Location: 1254704..1255066 (363 bp)
Type: Antitoxin
Protein ID: WP_008783109.1
Location: 1255212..1257911 (2700 bp)
Type: Others
Protein ID: WP_008783110.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BLGA_RS053851249283..1250515+1233WP_007056207.1sensor histidine kinase-
BLGA_RS053901250550..1251275+726WP_007056206.1response regulator transcription factor-
BLGA_RS053951251315..1251956+642WP_007052627.1GNAT family N-acetyltransferase-
BLGA_RS054001252046..1254151+2106WP_007052626.1DUF262 domain-containing protein-
BLGA_RS054051254213..1254704-492WP_007054468.1PIN domain-containing proteinToxin
BLGA_RS054101254704..1255066-363WP_008783109.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
BLGA_RS054151255212..1257911-2700WP_008783110.1aconitate hydratase AcnA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--1198926..126373564809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18328.91 Da        Isoelectric Point: 4.5590

>T35535 WP_007054468.1 NZ_AP022379:c1254704-1254213 [Bifidobacterium longum subsp. longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNITLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T35535 NZ_AP022379:c1254704-1254213 [Bifidobacterium longum subsp. longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACATTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13974.03 Da        Isoelectric Point: 5.0733

>AT35535 WP_008783109.1 NZ_AP022379:c1255066-1254704 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Download         Length: 363 bp

>AT35535 NZ_AP022379:c1255066-1254704 [Bifidobacterium longum subsp. longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTACACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBV6XWY1

Antitoxin

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Source
ID
Structure
AlphaFold DBV6XX41

References