Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3915808..3916487 Replicon chromosome
Accession NZ_AP022378
Organism Citrobacter portucalensis strain IOMTU157

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1B7JLK7
Locus tag IOMTU157_RS18945 Protein ID WP_003031349.1
Coordinates 3916146..3916487 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A1B7JLJ2
Locus tag IOMTU157_RS18940 Protein ID WP_003031347.1
Coordinates 3915808..3916125 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOMTU157_RS18915 3911901..3913898 - 1998 WP_016245729.1 choline BCCT transporter BetT -
IOMTU157_RS18920 3914402..3914593 + 192 Protein_3714 DUF905 family protein -
IOMTU157_RS18925 3914607..3915068 + 462 WP_003031344.1 antirestriction protein -
IOMTU157_RS18930 3915084..3915560 + 477 WP_003031345.1 RadC family protein -
IOMTU157_RS18935 3915569..3915790 + 222 WP_003031346.1 DUF987 domain-containing protein -
IOMTU157_RS18940 3915808..3916125 + 318 WP_003031347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IOMTU157_RS18945 3916146..3916487 + 342 WP_003031349.1 type IV toxin-antitoxin system toxin YkfI Toxin
IOMTU157_RS18955 3917118..3917582 - 465 WP_164563096.1 isoprenylcysteine carboxylmethyltransferase family protein -
IOMTU157_RS18960 3917848..3919296 - 1449 WP_164563097.1 EAL domain-containing protein -
IOMTU157_RS18965 3919814..3920509 - 696 WP_126319144.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3855390..3920509 65119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12921.01 Da        Isoelectric Point: 9.6543

>T35530 WP_003031349.1 NZ_AP022378:3916146-3916487 [Citrobacter portucalensis]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

>T35530 NZ_AP022378:3916146-3916487 [Citrobacter portucalensis]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATAGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGCAACAACGTAGTACGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12094.74 Da        Isoelectric Point: 7.0370

>AT35530 WP_003031347.1 NZ_AP022378:3915808-3916125 [Citrobacter portucalensis]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIEYRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT35530 NZ_AP022378:3915808-3916125 [Citrobacter portucalensis]
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JLK7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JLJ2

References