Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 4030474..4031059 Replicon chromosome
Accession NZ_AP022375
Organism Providencia rettgeri strain BML2576

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag G7Y69_RS18365 Protein ID WP_004905874.1
Coordinates 4030474..4030791 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag G7Y69_RS18370 Protein ID WP_004905876.1
Coordinates 4030772..4031059 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y69_RS18335 4026177..4026428 - 252 WP_094961642.1 DUF1471 domain-containing protein -
G7Y69_RS18340 4026699..4027037 + 339 WP_004905864.1 GIY-YIG nuclease family protein -
G7Y69_RS18345 4027010..4027513 - 504 WP_004905865.1 N-acetyltransferase -
G7Y69_RS18350 4027507..4028031 - 525 WP_094961643.1 SCP2 domain-containing protein -
G7Y69_RS18355 4028546..4029541 + 996 WP_094961644.1 U32 family peptidase -
G7Y69_RS18360 4029559..4030434 + 876 WP_094961645.1 U32 family peptidase -
G7Y69_RS18365 4030474..4030791 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
G7Y69_RS18370 4030772..4031059 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G7Y69_RS18375 4031190..4032344 - 1155 WP_004905877.1 ABC transporter permease -
G7Y69_RS18380 4032344..4033489 - 1146 WP_004905879.1 ABC transporter permease -
G7Y69_RS18385 4033501..4034472 - 972 WP_094961646.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T35513 WP_004905874.1 NZ_AP022375:c4030791-4030474 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

>T35513 NZ_AP022375:c4030791-4030474 [Providencia rettgeri]
TTGACTCAGAAGCCAAGTAATAAGCGAGCTAAGCAACCAAGGCAGGTTGCTTATACACCAACGTTTAAGAAGTCATGGGA
ACGATATAACCGAGCGGGCCGTAGGGATATGAATGCGGCTGTTCTCGTTATGGAAATACTGTTTTCTCAAAAAATAATAC
CAAAAGAATATCTTGACCATGAATTAGAAGGTCATGAATGGCAAGGAGCTAGGGAGCTTCATATTGGTGGTGATTTCTTA
CTGGTTTATCGCTTGTCAGATAAAGGTAATTTAATCACTTTCGTTGATATTGGTTCGCACAGTGAATTATTTGGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT35513 WP_004905876.1 NZ_AP022375:c4031059-4030772 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp

>AT35513 NZ_AP022375:c4031059-4030772 [Providencia rettgeri]
ATGTCAACACTATTGAAAACAACAGATGTTCGTAGTCGAATTGATGAACAATTAAAAGCGGAAGCCACGAGTGTATTACA
AGATTGTGGTTTGACTATTAGCGCAGCTATTCGTTTGTTTTTAGAACAAGTAGTTCAAGAGCAAAGAGTTCCCTTTGAAA
TCAAACGTAAGCAACCTTCGCTGAAAACTACACTAGCGTTGAAAGAAGCTAAAGCTATTGAGCAGCACTACGATTCAATT
AACGAAATGATGGTGGAGTTAAGCAAAGTTGACTCAGAAGCCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References