Detailed information of TA system TA035511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2433644..2434560
• Replicon: chromosome
• Accession: NZ_AP022375
• Organism: Providencia rettgeri strain BML2576

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: G7Y69_RS10990
• Protein ID: WP_164455662.1
• Coordinates: 2434102..2434560 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: D4BTW8
• Locus tag: G7Y69_RS10985
• Protein ID: WP_004254502.1
• Coordinates: 2433644..2434105 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7Y69_RS10955	2429307..2429921	+	615	WP_004254484.1	LysE family translocator	-
G7Y69_RS10960	2429951..2430424	-	474	WP_036957747.1	NUDIX domain-containing protein	-
G7Y69_RS10965	2430776..2431417	-	642	WP_004254492.1	leucine efflux protein LeuE	-
G7Y69_RS10970	2431888..2432589	+	702	WP_004254495.1	AzlC family ABC transporter permease	-
G7Y69_RS10975	2432586..2432900	+	315	WP_094960595.1	AzlD domain-containing protein	-
G7Y69_RS10980	2433088..2433555	+	468	WP_094960596.1	DUF1456 family protein	-
G7Y69_RS10985	2433644..2434105	+	462	WP_004254502.1	DUF2384 domain-containing protein	Antitoxin
G7Y69_RS10990	2434102..2434560	+	459	WP_164455662.1	RES domain-containing protein	Toxin
G7Y69_RS10995	2434561..2435451	-	891	WP_094960598.1	LysR family transcriptional regulator	-
G7Y69_RS11000	2435497..2436456	-	960	WP_164455664.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
G7Y69_RS11005	2436562..2436984	-	423	WP_094960600.1	helix-turn-helix domain-containing protein	-
G7Y69_RS11010	2437015..2437578	-	564	WP_004254518.1	GNAT family N-acetyltransferase	-
G7Y69_RS11015	2437559..2439025	-	1467	WP_036957754.1	AMP nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-145)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (38-95)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17158.71 Da
• Isoelectric Point: 6.4824

>T35511 WP_164455662.1 NZ_AP022375:2434102-2434560 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDRLLNQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKALHTVKPLDFSVDPRLA

Nucleotide

• Length: 459 bp

>T35511 NZ_AP022375:2434102-2434560 [Providencia rettgeri]
ATGATTTTATATCGATTGGTTAAATCCAATTTTGCGCATGATGCATGGTCGGGCCAAGGAGCTATGCTCTACGGCGGGCG
TTGGAATCATAAAGGGACTCCTGCTGTTTATACTTCAACAAGTATTTCATTAGCGACCCTTGAAATACTCGTTCACATCA
ATCAAGACAGACTATTGAACCAGTTCAGCTTACTATCCATAGATATCAATGATAAGTACGTGATGAAATTGTCGTTAGAT
CACCTTCCGACAGATTGGCAACAAGACCCCGCACCAACCTCCACCATGGATATTGGCACTATATGGCTTAATAACCAAGA
TAGTCTAGCATTATTAATTCCCTCTTGTATTGTTCCCTATGAATACAACGCAATTATTAACCCGTTACATCCGCAATTTC
AAAAAGCTTTACATACCGTTAAACCACTAGATTTTAGTGTTGACCCGCGCTTAGCATAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17090.56 Da
• Isoelectric Point: 9.9140

>AT35511 WP_004254502.1 NZ_AP022375:2433644-2434105 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT35511 NZ_AP022375:2433644-2434105 [Providencia rettgeri]
ATGAGAAACTATATCCCCACAACCCCACTTCAACCGACTGCTTCATCCTTTAAACCACTGTGGCGCCATGTAGGGTTACC
CGCAGAACGTGGTATTGAGTTAACTCATTTCTTGCGTCAAGGCCTATCTGTCTCTGTCTTAGACAATATCCAAGAATGGT
CAGGAATGAGCAAAACTGAATTATTGCGAATATCCGGCATTAATGAGCGCAATATTGCTCGACGTAAAAATGCTGGCCAG
CCCCTTAATGCTGATGAAAGTGAGAGAATTGCTCGTCTAGTGCGGGTATTCGATGCTGCGGTGCGTTTATTTAATGGAGA
TAAGCACGCGGCAAGTGATTGGCTTAACCACCCAGTTAAAGGGTTAGGACATTTACGCCCTATTGAGCTTATTGCGACAG
AAAGCGGAGCCATTGAAGTGATTGATTTGATTGGCCGTATTGAACATGGCGTATTCTCATGA

Structures

Antitoxin

• AlphaFold DB: A0A6G6Q7V6