Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3911441..3913163 Replicon chromosome
Accession NZ_AP022374
Organism Providencia stuartii strain BML2537

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag G7Y71_RS18235 Protein ID WP_141173074.1
Coordinates 3911441..3912379 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag G7Y71_RS18240 Protein ID WP_141173081.1
Coordinates 3912372..3913163 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y71_RS18215 3907382..3907894 - 513 WP_169636932.1 S26 family signal peptidase -
G7Y71_RS18220 3907878..3908225 - 348 WP_141173072.1 plasmid-related protein -
G7Y71_RS18225 3908218..3910617 - 2400 Protein_3542 type IV secretion system protein TraC -
G7Y71_RS18230 3910617..3911309 - 693 WP_141173073.1 DsbC family protein -
G7Y71_RS18235 3911441..3912379 - 939 WP_141173074.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
G7Y71_RS18240 3912372..3913163 - 792 WP_141173081.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
G7Y71_RS18245 3913383..3913769 - 387 WP_141173075.1 hypothetical protein -
G7Y71_RS18250 3913766..3914338 - 573 Protein_3547 type IV conjugative transfer system lipoprotein TraV -
G7Y71_RS18255 3914413..3915702 - 1290 WP_141173076.1 TraB/VirB10 family protein -
G7Y71_RS18260 3915705..3916601 - 897 WP_141173082.1 type-F conjugative transfer system secretin TraK -
G7Y71_RS18265 3916585..3917211 - 627 WP_141173077.1 pilus assembly protein -
G7Y71_RS18270 3917208..3917489 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
G7Y71_RS18275 3917723..3918013 + 291 WP_141173078.1 HigA family addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3696133..3934075 237942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-279)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35544.86 Da        Isoelectric Point: 5.0082

>T35506 WP_141173074.1 NZ_AP022374:c3912379-3911441 [Providencia stuartii]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVKESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPIMLLELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLVKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T35506 NZ_AP022374:c3912379-3911441 [Providencia stuartii]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGGTTAATGTCAGGGCTGCATTGCAGCGGATTACAGACAGAATAAATACTCAA
CCAGATATCCGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATCGTTGTATCAAGTCCGGTTGCGACAATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACACTGCATAGTGCAGAGATAATGCCAGTTAAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTAGTGGGTTTTTTAACCTA
TACACTAAGTCATCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAACCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCTATCATGTTACTTGAACTGCAAAAA
CATTTCACTGAAAGGGATCATGCCTTCCTCATGTCATTCAAAAGAGGGCAGCCTGACTGGGCATTGTTTGATTATCCTAA
TGCAGCAGACTTGCCTGCGATTCGTTGGAAGTTACAGAACATTAATAAATTGGTAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30116.50 Da        Isoelectric Point: 9.1901

>AT35506 WP_141173081.1 NZ_AP022374:c3913163-3912372 [Providencia stuartii]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLELNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT35506 NZ_AP022374:c3913163-3912372 [Providencia stuartii]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
TGTGAGCTATTCCTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTAAAGAAGCTATGTTCTGGCGTGTATTATCGTCCAG
ATGCGCAGGGTGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTAGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAGGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCAAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAC
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAACTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGACGGGATTGGGAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References