Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3699519..3700169 Replicon chromosome
Accession NZ_AP022374
Organism Providencia stuartii strain BML2537

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag G7Y71_RS17305 Protein ID WP_004927064.1
Coordinates 3699966..3700169 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag G7Y71_RS17300 Protein ID WP_004927067.1
Coordinates 3699519..3699887 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y71_RS17275 3694656..3695417 - 762 WP_004927092.1 DNA polymerase III subunit epsilon -
G7Y71_RS17280 3695472..3695942 + 471 WP_014656762.1 ribonuclease HI -
G7Y71_RS17285 3696021..3696746 - 726 WP_040132836.1 methyltransferase domain-containing protein -
G7Y71_RS17290 3696780..3697535 + 756 WP_076914490.1 hydroxyacylglutathione hydrolase -
G7Y71_RS17295 3697614..3698951 + 1338 WP_004927077.1 murein transglycosylase D -
G7Y71_RS17300 3699519..3699887 + 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
G7Y71_RS17305 3699966..3700169 + 204 WP_004927064.1 hemolysin expression modulator Hha Toxin
G7Y71_RS17315 3700775..3701233 - 459 WP_004927062.1 YbaY family lipoprotein -
G7Y71_RS17320 3701556..3702422 + 867 WP_004927058.1 acyl-CoA thioesterase II -
G7Y71_RS17325 3702659..3703942 - 1284 WP_014656764.1 ammonium transporter AmtB -
G7Y71_RS17330 3703953..3704291 - 339 WP_004927053.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3696133..3934075 237942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T35505 WP_004927064.1 NZ_AP022374:3699966-3700169 [Providencia stuartii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T35505 NZ_AP022374:3699966-3700169 [Providencia stuartii]
ATGACCAAAACTGATTATCTGATGCGTTTAAGAAAATGCACAACCATCGATACACTTGAGCGTGTTATTGAGAAAAATAA
GTATGAGCTTTCTGAAGATGAGTTAGAATTGTTCTATTCAGCTGCTGACCATCGCCTTGCAGAACTCACTATGAATAAAC
TTTATGACAAAATCCCTGCATCGGTTTGGAAATTTGTTAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT35505 WP_004927067.1 NZ_AP022374:3699519-3699887 [Providencia stuartii]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp

>AT35505 NZ_AP022374:3699519-3699887 [Providencia stuartii]
ATGGATGAATATTCACCCAAAAATTATGATATATCTGAGTTAAAATACTTGTGTAACAGTTTGAATCGAGAAGCAATGTT
AAGCTTACAGAAAACTAATACACACTGGGTCAATGATTTAAGTTCACCACAAAGTGCTAGACTTAATGAACTCATTGAAC
ATATTGCAGCCTTCGTGTGGCAATTTAAGATAAAATATCCCAAAGAGAATCTCGTTATATCATTAGTTGAAGAGTATCTT
GATGAGACTTATGATTTATTCGGAAGCCCTGTAATAACTCTAAGTGAAATTATTGACTGGCAGAGCATGAATCAAAATCT
AGTTTCCGTACTTGATGATGATTTAAAGTGCCCTGCAAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References