Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3018080..3018737 Replicon chromosome
Accession NZ_AP022374
Organism Providencia stuartii strain BML2537

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1H2A7
Locus tag G7Y71_RS14210 Protein ID WP_036941148.1
Coordinates 3018080..3018490 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID B2Q1I8
Locus tag G7Y71_RS14215 Protein ID WP_004921708.1
Coordinates 3018471..3018737 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y71_RS14190 3013967..3015700 - 1734 WP_004921693.1 single-stranded-DNA-specific exonuclease RecJ -
G7Y71_RS14195 3015706..3016410 - 705 WP_141173653.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G7Y71_RS14200 3016430..3017353 - 924 WP_141173654.1 site-specific tyrosine recombinase XerD -
G7Y71_RS14205 3017516..3018034 + 519 WP_014656387.1 flavodoxin FldB -
G7Y71_RS14210 3018080..3018490 - 411 WP_036941148.1 membrane protein Toxin
G7Y71_RS14215 3018471..3018737 - 267 WP_004921708.1 FAD assembly factor SdhE Antitoxin
G7Y71_RS14220 3018990..3019979 + 990 WP_141173655.1 tRNA-modifying protein YgfZ -
G7Y71_RS14225 3019991..3020611 + 621 WP_004921714.1 HD domain-containing protein -
G7Y71_RS14230 3020830..3023706 - 2877 WP_141173656.1 aminomethyl-transferring glycine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15289.15 Da        Isoelectric Point: 10.8779

>T35504 WP_036941148.1 NZ_AP022374:c3018490-3018080 [Providencia stuartii]
VVLWKSNLSISWKTQLFSTCAHGVVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T35504 NZ_AP022374:c3018490-3018080 [Providencia stuartii]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACTCAGCTTTTTTCAACCTGTGCTCATGGGGTAGTCGGCTT
TATTCTATTGGTCGCACCATGGGCGCCAGGGAATTCAATGGTGTGGTTGCCGCTGTTAGTGATTGTGATTGCTAGCTGGG
CAAAAAGCCAAAAAAGCATCAGCAAAATCAAAGGGACTGCGGTACTGGTTAATGGCAATAAAGTCCAATGGAAAAAGAAT
GAGTGGAGTATCGTTAAGCAACCTTGGTGTAGCCGTGTGGGGGTATTATTGACACTCAGTGCCTTACAAGGTAAGCCACA
GAAGATCCGTTTATGGGTTGCAAAAGATGCCTTATCAGAAGAGAGCTGGCGTAATTTAAACCAACTATTACTGCAATATC
CTGATATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10576.10 Da        Isoelectric Point: 4.9104

>AT35504 WP_004921708.1 NZ_AP022374:c3018737-3018471 [Providencia stuartii]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT35504 NZ_AP022374:c3018737-3018471 [Providencia stuartii]
ATGGATATAGAGAATAAAGCAAGAATTCATTGGGCTTGCCGTCGTGGTATGCGTGAGTTGGATATTTCCATCATGCCATT
CTTTGAATATGAATATGAAGGACTCTCTGACAAGGACAAGCGTACTTTTGTTCGTTTACTTGAGTGTGCAGACCCTGATC
TGTTTAACTGGTTAATGAATCATGGGCGCCCAGACGACGATGAGTTGTTTGGTATGGTTAAATTGATTCAGGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1H2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A140NIX0

References