Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4689820..4691396 Replicon chromosome
Accession NZ_AP022373
Organism Providencia rettgeri strain BML2531

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag G7Y73_RS21760 Protein ID WP_140172675.1
Coordinates 4689820..4691139 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag G7Y73_RS21765 Protein ID WP_036959176.1
Coordinates 4691139..4691396 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y73_RS21750 4685757..4688804 - 3048 WP_094961978.1 formate dehydrogenase-N subunit alpha -
G7Y73_RS21755 4688979..4689809 + 831 WP_036959175.1 formate dehydrogenase accessory sulfurtransferase FdhD -
G7Y73_RS21760 4689820..4691139 - 1320 WP_140172675.1 type II toxin-antitoxin system HipA family toxin Toxin
G7Y73_RS21765 4691139..4691396 - 258 WP_036959176.1 helix-turn-helix domain-containing protein Antitoxin
G7Y73_RS21770 4691726..4693090 - 1365 WP_004906223.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
G7Y73_RS21775 4693192..4694841 - 1650 WP_004906225.1 membrane protein insertase YidC -
G7Y73_RS21780 4694844..4695104 - 261 WP_036959180.1 membrane protein insertion efficiency factor YidD -
G7Y73_RS21785 4695068..4695427 - 360 WP_004906229.1 ribonuclease P protein component -
G7Y73_RS21790 4695449..4695592 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50013.00 Da        Isoelectric Point: 6.5676

>T35503 WP_140172675.1 NZ_AP022373:c4691139-4689820 [Providencia rettgeri]
MATLHVYMNGYLVGDLIRSSTGAHQFTYNSHWLETSGARPISLSMPLRHQEYRGDEVYNFFDNLLPDNIEIRNRIVSRYQ
ADSNQPFDLLSKIGQDSVGALQLILDGQRVSNIRKIEYKPLSNKQLEKILTGYKANAPLGMIEDEDDFRISLAGAQEKTA
LLYLDGHWCLPQNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKEFGLDVPYSFILNVGEIKALAVERFDRK
YSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNYLLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRGMKYNIEQIFPRHFFSTAKAVGFDRAEMEKILIEFGEQM
ESVIKKVREQLPTDFPEHIADSILSGLHHKAARLNKGWD

Download         Length: 1320 bp

>T35503 NZ_AP022373:c4691139-4689820 [Providencia rettgeri]
ATGGCGACTTTGCATGTATACATGAATGGTTACTTAGTTGGGGATTTGATTCGTTCAAGTACTGGTGCTCACCAATTTAC
ATATAATAGTCACTGGTTGGAAACATCAGGTGCTCGACCTATTTCTTTATCAATGCCACTTAGGCACCAAGAATATCGAG
GAGACGAAGTTTATAATTTTTTTGATAATCTCCTACCGGACAATATTGAGATACGGAATCGAATTGTTAGTCGTTATCAA
GCGGATTCAAATCAACCTTTCGATTTATTATCTAAGATTGGTCAGGATAGTGTGGGGGCTTTACAACTCATTCTAGATGG
GCAAAGAGTCAGTAATATCAGAAAAATTGAATATAAACCCTTATCTAATAAGCAACTAGAAAAAATATTAACAGGGTATA
AAGCGAATGCTCCTTTAGGCATGATTGAAGATGAAGATGACTTTAGGATCTCACTTGCGGGCGCTCAAGAGAAAACCGCA
TTACTCTATTTAGATGGGCATTGGTGCTTACCTCAGAATGCGACTCCAACTACCCATATTATTAAACTTCCCATTGGTAA
AATAGAAAGCCATTCTTATTCGATAGATATGTCGGATAGTGTAGAAAATGAATATTTATGTTTATTGATAGCAAAAGAGT
TTGGCCTAGATGTGCCCTATAGCTTTATTTTAAATGTAGGTGAAATAAAGGCGTTAGCGGTTGAACGTTTTGACCGTAAA
TATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATTTTTGTCAAACATTGAATATTTCACCAGCAAGAAA
ATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTACTTATTGGGTTCAATAAATGCAGAGAAAGATAGAT
ATCAGTTTATGAAGAGCCAAGTTTTGTTCTGGCTACTTGCAGCGACGGATGGTCATGCTAAAAATTTTTCATTATTTATT
GAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGTCCATGTATCCTAGTTATGGGGGGAGGGGAATTAA
CCCTAGAGATGCCAAATTGGCTATGGGGCTGAAGGGAACAAGGGGGATGAAATACAATATAGAGCAAATTTTCCCAAGAC
ATTTTTTTTCAACGGCCAAAGCCGTTGGATTTGATCGTGCTGAGATGGAAAAAATCTTAATTGAATTTGGTGAGCAAATG
GAAAGTGTTATTAAGAAAGTGAGAGAACAATTACCCACAGATTTCCCTGAGCATATCGCAGACTCAATTCTATCCGGATT
ACATCACAAAGCAGCGAGATTAAATAAAGGCTGGGACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9628.85 Da        Isoelectric Point: 9.6898

>AT35503 WP_036959176.1 NZ_AP022373:c4691396-4691139 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSDSG
WKEEW

Download         Length: 258 bp

>AT35503 NZ_AP022373:c4691396-4691139 [Providencia rettgeri]
ATGAAAGTGACGAATACCCGACAACTTAGTGCTTATATGAAGGATGTCAGAGAGACGAAAAAGTTATCTCAAAGCAAAGT
CGCTAGTAAAGTAGGTATTCGGCAAGATACTGTTTCTAGCTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTTT
TTAAGATTTTATCTGCCCTCAATTTAGAACTCGATATTAAACCGCGAAATGAAAGTGGCTCATCAAATTCAGACTCCGGA
TGGAAGGAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References