35502

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4588609..4589192 Replicon chromosome
Accession NZ_AP022373
Organism Providencia rettgeri strain BML2531

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag G7Y73_RS21300 Protein ID WP_096863599.1
Coordinates 4588890..4589192 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G7Y73_RS21295 Protein ID WP_004265229.1
Coordinates 4588609..4588893 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y73_RS21270 4583770..4584747 - 978 WP_004265237.1 6-phosphofructokinase -
G7Y73_RS21275 4585154..4586098 - 945 WP_004265235.1 phosphatidate cytidylyltransferase -
G7Y73_RS21280 4586095..4586736 - 642 WP_094961883.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
G7Y73_RS21285 4586974..4587726 - 753 WP_004265231.1 M48 family metallopeptidase -
G7Y73_RS21290 4587945..4588526 - 582 WP_004265230.1 HutD family protein -
G7Y73_RS21295 4588609..4588893 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
G7Y73_RS21300 4588890..4589192 - 303 WP_096863599.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7Y73_RS21305 4589448..4590017 - 570 WP_110592812.1 Spy/CpxP family protein refolding chaperone -
G7Y73_RS21310 4590168..4590866 + 699 WP_004265224.1 envelope stress response regulator transcription factor CpxR -
G7Y73_RS21315 4590863..4592233 + 1371 WP_164565639.1 envelope stress sensor histidine kinase CpxA -
G7Y73_RS21320 4592705..4594141 + 1437 WP_164565640.1 capsule assembly Wzi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11433.37 Da        Isoelectric Point: 10.0723

>T35502 WP_096863599.1 NZ_AP022373:c4589192-4588890 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

>T35502 NZ_AP022373:c4589192-4588890 [Providencia rettgeri]
ATGATCACGGTTCTAACAACGGAATGTTTTGATAGTTGGATCAAAAATCTTAGAGATATTCGAGCTAAAACTAAAATTCT
AATGAGAATTAGGCGGTTAAAAAATGGAAATTATGGTGATGTTCAACCCATTGGTGATGGCTTTTCGGAACTGAGGGTAC
ATGAAGGACAAGGGTATCGTGTTTATCTAAAGCAGAAAAACAATGTTATTGTAATTTTACTTTGTGGTGGGACAAAGGCA
ACGCAGCAGAAGGATATCCATAAAGCTAAACTCCTTTTTGGTGAAGTTGAGGGGGAACTATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT35502 WP_004265229.1 NZ_AP022373:c4588893-4588609 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT35502 NZ_AP022373:c4588893-4588609 [Providencia rettgeri]
ATGAATACTAAATTAAAAGAATTTGATATCGCTGAGTATTTAAACAGTGAAGAAGAAATACAAATGTATCTAAACGAAAT
TCTAGAAGAAGGTGACCCTAGTCTAGTTCTCGCTGCACTTGGTGATATTGCGAAGGCAAGAAATATGAGCCAATTAGCTA
AAGAAGTTGGAATGAGTCGTGAAGGTTTATATAAGGCGCTATCAGGACAGGGAAATCCAACATTTATGACGATTATAAAA
ATCGTTAATTCTCTCGGATTAAAGCTACAGTTTAAGAGTATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References