Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4320565..4321318 Replicon chromosome
Accession NZ_AP022373
Organism Providencia rettgeri strain BML2531

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G7Y73_RS19965 Protein ID WP_004905886.1
Coordinates 4320884..4321318 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G7Y73_RS19960 Protein ID WP_004905885.1
Coordinates 4320565..4320894 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y73_RS19945 4316634..4317605 - 972 WP_004905881.1 efflux RND transporter periplasmic adaptor subunit -
G7Y73_RS19950 4318139..4319824 + 1686 WP_094961673.1 sensor histidine kinase -
G7Y73_RS19955 4319844..4320560 + 717 WP_004905884.1 two-component system response regulator BtsR -
G7Y73_RS19960 4320565..4320894 - 330 WP_004905885.1 helix-turn-helix domain-containing protein Antitoxin
G7Y73_RS19965 4320884..4321318 - 435 WP_004905886.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7Y73_RS19970 4321427..4323358 - 1932 WP_004905887.1 DEAD/DEAH family ATP-dependent RNA helicase -
G7Y73_RS19975 4323529..4324395 - 867 WP_004905888.1 lipoprotein NlpI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(19-139)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-93)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 16099.74 Da        Isoelectric Point: 9.3330

>T35501 WP_004905886.1 NZ_AP022373:c4321318-4320884 [Providencia rettgeri]
MALATIVIGTTWRVVVAFYKISSFKRSTKKIKIMDKHLLKAANEVLAGVYEADLGSGVIKKRIAINGKGKSGGGRVIIFF
KVSHHLFFADGWEKCNIAAKGVKEIEDDELDAYKNLSRLFLNYTDDKIADLVLHNILEELTDEQ

Download         Length: 435 bp

>T35501 NZ_AP022373:c4321318-4320884 [Providencia rettgeri]
ATGGCACTTGCTACTATAGTAATAGGTACTACATGGAGAGTAGTTGTGGCGTTCTATAAAATTTCCTCATTTAAGCGAAG
CACCAAAAAAATTAAGATAATGGATAAACACTTGCTTAAGGCTGCAAATGAAGTCTTAGCGGGGGTTTATGAAGCAGACT
TAGGAAGTGGTGTAATTAAAAAAAGGATTGCCATTAATGGAAAAGGGAAAAGTGGTGGGGGCAGGGTTATTATATTCTTC
AAAGTTAGCCATCATCTCTTTTTTGCCGATGGTTGGGAGAAATGCAATATAGCTGCTAAAGGAGTAAAAGAAATTGAAGA
TGATGAACTAGATGCGTATAAGAATTTATCTCGACTTTTTCTTAATTATACGGATGATAAAATTGCTGATTTAGTTTTAC
ATAATATTTTGGAGGAGCTTACTGATGAGCAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12235.50 Da        Isoelectric Point: 10.3803

>AT35501 WP_004905885.1 NZ_AP022373:c4320894-4320565 [Providencia rettgeri]
MSNKLENMLELAKELHQVDAAPKSLVTDLEQKVGNRKINNKIKVVPMMSGAQIKQLRAQYGMSQAMLALALGMSKESVSK
WEREEKKPSGPALRMLHLIEQRGPEILII

Download         Length: 330 bp

>AT35501 NZ_AP022373:c4320894-4320565 [Providencia rettgeri]
ATGAGCAATAAACTAGAAAACATGCTTGAGCTAGCGAAAGAGTTACATCAGGTTGATGCTGCACCAAAAAGTTTAGTTAC
TGATTTAGAACAGAAGGTTGGAAATCGTAAAATAAATAATAAAATCAAGGTAGTACCTATGATGAGCGGTGCGCAAATCA
AACAACTCCGTGCTCAATATGGAATGTCACAAGCCATGTTAGCTTTAGCGCTGGGCATGTCTAAGGAAAGCGTATCTAAG
TGGGAAAGAGAAGAAAAAAAACCCAGTGGCCCAGCTCTAAGAATGCTACATCTTATAGAGCAGCGAGGGCCAGAGATTTT
AATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References