Detailed information of TA system TA035501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 4320565..4321318
• Replicon: chromosome
• Accession: NZ_AP022373
• Organism: Providencia rettgeri strain BML2531

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G7Y73_RS19965
• Protein ID: WP_004905886.1
• Coordinates: 4320884..4321318 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G7Y73_RS19960
• Protein ID: WP_004905885.1
• Coordinates: 4320565..4320894 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7Y73_RS19945	4316634..4317605	-	972	WP_004905881.1	efflux RND transporter periplasmic adaptor subunit	-
G7Y73_RS19950	4318139..4319824	+	1686	WP_094961673.1	sensor histidine kinase	-
G7Y73_RS19955	4319844..4320560	+	717	WP_004905884.1	two-component system response regulator BtsR	-
G7Y73_RS19960	4320565..4320894	-	330	WP_004905885.1	helix-turn-helix domain-containing protein	Antitoxin
G7Y73_RS19965	4320884..4321318	-	435	WP_004905886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G7Y73_RS19970	4321427..4323358	-	1932	WP_004905887.1	DEAD/DEAH family ATP-dependent RNA helicase	-
G7Y73_RS19975	4323529..4324395	-	867	WP_004905888.1	lipoprotein NlpI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (19-139)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-93)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16099.74 Da
• Isoelectric Point: 9.3330

>T35501 WP_004905886.1 NZ_AP022373:c4321318-4320884 [Providencia rettgeri]
MALATIVIGTTWRVVVAFYKISSFKRSTKKIKIMDKHLLKAANEVLAGVYEADLGSGVIKKRIAINGKGKSGGGRVIIFF
KVSHHLFFADGWEKCNIAAKGVKEIEDDELDAYKNLSRLFLNYTDDKIADLVLHNILEELTDEQ

Nucleotide

• Length: 435 bp

>T35501 NZ_AP022373:c4321318-4320884 [Providencia rettgeri]
ATGGCACTTGCTACTATAGTAATAGGTACTACATGGAGAGTAGTTGTGGCGTTCTATAAAATTTCCTCATTTAAGCGAAG
CACCAAAAAAATTAAGATAATGGATAAACACTTGCTTAAGGCTGCAAATGAAGTCTTAGCGGGGGTTTATGAAGCAGACT
TAGGAAGTGGTGTAATTAAAAAAAGGATTGCCATTAATGGAAAAGGGAAAAGTGGTGGGGGCAGGGTTATTATATTCTTC
AAAGTTAGCCATCATCTCTTTTTTGCCGATGGTTGGGAGAAATGCAATATAGCTGCTAAAGGAGTAAAAGAAATTGAAGA
TGATGAACTAGATGCGTATAAGAATTTATCTCGACTTTTTCTTAATTATACGGATGATAAAATTGCTGATTTAGTTTTAC
ATAATATTTTGGAGGAGCTTACTGATGAGCAATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12235.50 Da
• Isoelectric Point: 10.3803

>AT35501 WP_004905885.1 NZ_AP022373:c4320894-4320565 [Providencia rettgeri]
MSNKLENMLELAKELHQVDAAPKSLVTDLEQKVGNRKINNKIKVVPMMSGAQIKQLRAQYGMSQAMLALALGMSKESVSK
WEREEKKPSGPALRMLHLIEQRGPEILII

Nucleotide

• Length: 330 bp

>AT35501 NZ_AP022373:c4320894-4320565 [Providencia rettgeri]
ATGAGCAATAAACTAGAAAACATGCTTGAGCTAGCGAAAGAGTTACATCAGGTTGATGCTGCACCAAAAAGTTTAGTTAC
TGATTTAGAACAGAAGGTTGGAAATCGTAAAATAAATAATAAAATCAAGGTAGTACCTATGATGAGCGGTGCGCAAATCA
AACAACTCCGTGCTCAATATGGAATGTCACAAGCCATGTTAGCTTTAGCGCTGGGCATGTCTAAGGAAAGCGTATCTAAG
TGGGAAAGAGAAGAAAAAAAACCCAGTGGCCCAGCTCTAAGAATGCTACATCTTATAGAGCAGCGAGGGCCAGAGATTTT
AATTATTTAA