Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1915308..1915956 Replicon chromosome
Accession NZ_AP022373
Organism Providencia rettgeri strain BML2531

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G7Y73_RS08520 Protein ID WP_094961724.1
Coordinates 1915771..1915956 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G7Y73_RS08515 Protein ID WP_164565692.1
Coordinates 1915308..1915721 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y73_RS08490 1910623..1911759 - 1137 WP_036958991.1 M4 family metallopeptidase -
G7Y73_RS08495 1911918..1912835 - 918 WP_004264888.1 oxygen-dependent coproporphyrinogen oxidase -
G7Y73_RS08500 1912972..1913403 + 432 WP_004264887.1 GNAT family acetyltransferase -
G7Y73_RS08505 1913495..1914100 + 606 WP_050763802.1 RpoE-regulated lipoprotein -
G7Y73_RS08510 1914343..1915242 + 900 WP_094961722.1 Dyp-type peroxidase -
G7Y73_RS08515 1915308..1915721 - 414 WP_164565692.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G7Y73_RS08520 1915771..1915956 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
G7Y73_RS08525 1916279..1917301 + 1023 WP_094961725.1 sulfate ABC transporter substrate-binding protein -
G7Y73_RS08530 1917301..1918131 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
G7Y73_RS08535 1918131..1918991 + 861 WP_164565098.1 sulfate/thiosulfate ABC transporter permease CysW -
G7Y73_RS08540 1918994..1920082 + 1089 WP_004264880.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T35497 WP_094961724.1 NZ_AP022373:c1915956-1915771 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T35497 NZ_AP022373:c1915956-1915771 [Providencia rettgeri]
GTGCAAAGTTCGGAACTGATAAACATACTGCAAAAAAACGGTTGGAAACTTGAAAGAATAAAAGGAAGTCACCATCAGTT
TTCCCACCCACATTTTTCAATTGTAATTACTGTTCCGCATCCACAAAAAGATTTAAAGATAGGCACACTAAATCACATTT
TGAAGGCTGCGAAACTAAAACATTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15372.33 Da        Isoelectric Point: 4.6719

>AT35497 WP_164565692.1 NZ_AP022373:c1915721-1915308 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDIDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAVAARKELKKTD

Download         Length: 414 bp

>AT35497 NZ_AP022373:c1915721-1915308 [Providencia rettgeri]
ATGCTTTATACCGCCTTTATTGAAATTGATAATGATGGCAGCGCAAGTGGCTGGTTTCCTGATATTGAAGGATGTACATT
CGCGGGCAGCAATATAGAAGAGGCTTACGCAGAAGCAAAATCAGCAATTGATGCTCATTTTGAATTATTGAGTGAAAAAG
GCTTTGAGATCCCATTATCGAAATCTCAGCAAACGCTATTGAACCCAATACAACCTGAATATGCGCATGGGATATGGTTA
TTTGTGGATGTCGATATCGATAAATACGATGGCCGTACTGAGCGTATTAATATCACCTTGCCGCATCGTTTATTACATCG
TATTGATGCTTTAGTGAAGGTTAATCCTGAATATGGTAGCCGTAGTGGTTTTATTGCTGTTGCAGCTCGTAAAGAATTAA
AAAAAACCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References