Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3061808..3062456 Replicon chromosome
Accession NZ_AP022372
Organism Providencia rettgeri strain BML2526

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag pBML2531_RS13890 Protein ID WP_094961724.1
Coordinates 3062271..3062456 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag pBML2531_RS13885 Protein ID WP_094961723.1
Coordinates 3061808..3062221 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
pBML2531_RS13860 3057123..3058259 - 1137 WP_164455470.1 M4 family metallopeptidase -
pBML2531_RS13865 3058418..3059335 - 918 WP_164455472.1 oxygen-dependent coproporphyrinogen oxidase -
pBML2531_RS13870 3059472..3059903 + 432 WP_110591954.1 GNAT family acetyltransferase -
pBML2531_RS13875 3059995..3060600 + 606 WP_050763802.1 RpoE-regulated lipoprotein -
pBML2531_RS13880 3060843..3061742 + 900 WP_164455474.1 Dyp-type peroxidase -
pBML2531_RS13885 3061808..3062221 - 414 WP_094961723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
pBML2531_RS13890 3062271..3062456 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
pBML2531_RS13895 3062779..3063801 + 1023 WP_164455476.1 sulfate ABC transporter substrate-binding protein -
pBML2531_RS13900 3063801..3064631 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
pBML2531_RS13905 3064631..3065491 + 861 WP_004264881.1 sulfate/thiosulfate ABC transporter permease CysW -
pBML2531_RS13910 3065494..3066582 + 1089 WP_004264880.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T35492 WP_094961724.1 NZ_AP022372:c3062456-3062271 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T35492 NZ_AP022372:c3062456-3062271 [Providencia rettgeri]
GTGCAAAGTTCGGAACTGATAAACATACTGCAAAAAAACGGTTGGAAACTTGAAAGAATAAAAGGAAGTCACCATCAGTT
TTCCCACCCACATTTTTCAATTGTAATTACTGTTCCGCATCCACAAAAAGATTTAAAGATAGGCACACTAAATCACATTT
TGAAGGCTGCGAAACTAAAACATTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.31 Da        Isoelectric Point: 4.6719

>AT35492 WP_094961723.1 NZ_AP022372:c3062221-3061808 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Download         Length: 414 bp

>AT35492 NZ_AP022372:c3062221-3061808 [Providencia rettgeri]
ATGCTTTATACCGCCTTTATTGAAATTGATAATGATGGCAGCGCAAGTGGCTGGTTTCCTGATATTGAAGGATGTACATT
CGCGGGCAGCAATATAGAAGAGGCTTACGCAGAAGCAAAATCAGCAATTGATGCTCATTTTGAATTATTGAGTGAAAAAG
GCTTTGAGATCCCATTATCGAAATCTCAGCAAACGCTATTGAACCCAATACAACCTGAATATGCGCATGGGATATGGTTA
TTTGTGGATGTCGATATGGATAAATACGATGGCCGTACTGAGCGTATTAATATCACCTTGCCGCATCGTTTATTACATCG
TATTGATGCTTTAGTGAAGGTTAATCCTGAATATGGTAGCCGTAGTGGTTTTATTGCTGCTGCAGCTCGTAAAGAATTAA
AAAAAACCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References