Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2831634..2832291 Replicon chromosome
Accession NZ_AP022372
Organism Providencia rettgeri strain BML2526

Toxin (Protein)


Gene name cptA Uniprot ID A0A264VM08
Locus tag pBML2531_RS12815 Protein ID WP_036958456.1
Coordinates 2831881..2832291 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4C097
Locus tag pBML2531_RS12810 Protein ID WP_004261864.1
Coordinates 2831634..2831900 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
pBML2531_RS12795 2828630..2829526 - 897 WP_164455303.1 hypothetical protein -
pBML2531_RS12800 2829771..2830391 - 621 WP_004261871.1 HD domain-containing protein -
pBML2531_RS12805 2830403..2831386 - 984 WP_004261867.1 tRNA-modifying protein YgfZ -
pBML2531_RS12810 2831634..2831900 + 267 WP_004261864.1 FAD assembly factor SdhE Antitoxin
pBML2531_RS12815 2831881..2832291 + 411 WP_036958456.1 protein YgfX Toxin
pBML2531_RS12820 2832391..2832909 - 519 WP_164455305.1 flavodoxin FldB -
pBML2531_RS12825 2833027..2833929 + 903 WP_004261814.1 site-specific tyrosine recombinase XerD -
pBML2531_RS12830 2833951..2834655 + 705 WP_164455307.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
pBML2531_RS12835 2834665..2836398 + 1734 WP_164455309.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15568.53 Da        Isoelectric Point: 10.7733

>T35491 WP_036958456.1 NZ_AP022372:2831881-2832291 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLAPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWRILKAPWLTRYGILLTLEALQGKPQKLHLWVAKDALSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T35491 NZ_AP022372:2831881-2832291 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACCCAACTGTTCTCAACCTGTGTTCATGGGGTCATTGGGAT
GTTTTTACTATTGGCTCCATGGTCCCCTGGTAACTCAATGATATGGTTGCCGCTATTAGTGGTTGTCGTTGCGAGTTGGG
CAAAGAGCCAGAAAAATATCAGTAAAATAAAAGGGGTTGCTGTACTGGTTAATGGCAATAAGGTTCAGTGGAAGAAAAAT
GAATGGAGAATACTGAAAGCACCTTGGCTTACCCGCTATGGTATATTACTGACACTAGAAGCGTTACAAGGTAAACCACA
AAAGCTCCATTTGTGGGTTGCAAAAGACGCATTGTCGGAAGAGAATTGGCGTAATTTAAACCAATTATTGCTGCAATACC
CTGATATTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10684.24 Da        Isoelectric Point: 4.8942

>AT35491 WP_004261864.1 NZ_AP022372:2831634-2831900 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDDLTTHDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT35491 NZ_AP022372:2831634-2831900 [Providencia rettgeri]
ATGGATATTGAGAATAAAGCGCGAATTCATTGGGCATGCCGCCGTGGTATGCGTGAATTAGATATTTCAATCATGCCGTT
TTTTGAGTATGAATATGATGACCTAACAACTCACGATAAGCAGGTATTTGTCCGTTTATTAGAATGTGCGGACCCTGATT
TATTCAATTGGCTAATGAATCACGGTCGTCCAGATGATGACGAACTTTTTCGTATGATTAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A264VM08

Antitoxin

Source ID Structure
AlphaFold DB A0A345M2Q5

References