Detailed information of TA system TA035490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2312448..2313147
• Replicon: chromosome
• Accession: NZ_AP022372
• Organism: Providencia rettgeri strain BML2526

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: pBML2531_RS10545
• Protein ID: WP_164455126.1
• Coordinates: 2312758..2313147 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: pBML2531_RS10540
• Protein ID: WP_164455124.1
• Coordinates: 2312448..2312765 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2255748..2316363	60615

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (3-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (49-90)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14340.61 Da
• Isoelectric Point: 6.3578

>T35490 WP_164455126.1 NZ_AP022372:c2313147-2312758 [Providencia rettgeri]
VGIYLTPEFEEERRSARISNAILCKAAKAIFSGLPGDPLGKFTYKKRLGLPGVGAKDGARSIVFFNNGENLFFFDMYLKS
ELSKKKGKELEADEINAYCNIAKDFIAMSSVMIKTLLTDKELIEVTCDD

Nucleotide

• Length: 390 bp

>T35490 NZ_AP022372:c2313147-2312758 [Providencia rettgeri]
GTGGGAATTTATTTAACACCTGAATTTGAGGAAGAACGCCGGAGCGCACGCATCAGTAATGCCATTTTGTGCAAAGCGGC
TAAAGCTATTTTTTCTGGTCTACCGGGCGATCCGCTAGGAAAATTCACCTACAAAAAGCGACTTGGCTTACCCGGAGTAG
GAGCGAAAGACGGTGCACGGTCAATTGTTTTTTTTAATAATGGCGAAAACCTATTTTTCTTTGATATGTATTTGAAAAGT
GAACTTTCCAAAAAGAAAGGAAAGGAGCTTGAAGCCGATGAAATTAATGCTTACTGCAATATCGCAAAAGATTTTATCGC
AATGAGTTCGGTAATGATAAAGACGTTGCTGACAGATAAAGAGCTGATTGAGGTGACTTGTGATGACTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11682.65 Da
• Isoelectric Point: 11.0022

>AT35490 WP_164455124.1 NZ_AP022372:c2312765-2312448 [Providencia rettgeri]
MTERLKRIQGMAERYNKLGVVRDETVAVIDAAVAARKIPAVRTMTGSQIKEVRTRYNMSQAALAMTTGMSVESVSKWERN
ESKPNKAALRIINIIDAKGPQVFMS

Nucleotide

• Length: 318 bp

>AT35490 NZ_AP022372:c2312765-2312448 [Providencia rettgeri]
ATGACTGAACGACTGAAACGCATTCAGGGCATGGCTGAGCGCTACAATAAATTAGGCGTGGTGAGAGATGAAACCGTCGC
GGTTATCGATGCTGCGGTCGCGGCCCGTAAAATACCGGCTGTCCGTACCATGACCGGTAGCCAGATTAAAGAAGTTCGCA
CTCGCTACAACATGTCACAAGCCGCACTGGCGATGACGACCGGCATGTCTGTAGAGAGTGTGTCGAAGTGGGAGAGAAAC
GAGAGCAAGCCGAACAAGGCCGCTTTGCGGATCATTAACATCATTGATGCTAAAGGGCCACAAGTATTTATGTCATAA