Detailed information of TA system TA035490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2312448..2313147
• Replicon: chromosome
• Accession: NZ_AP022372
• Organism: Providencia rettgeri strain BML2526

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: pBML2531_RS10545
• Protein ID: WP_164455126.1
• Coordinates: 2312758..2313147 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: pBML2531_RS10540
• Protein ID: WP_164455124.1
• Coordinates: 2312448..2312765 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
pBML2531_RS10505	2307693..2308595	+	903	WP_164455114.1	integrase domain-containing protein	-
pBML2531_RS10510	2308669..2309226	+	558	WP_197739547.1	DUF459 domain-containing protein	-
pBML2531_RS10515	2309707..2310234	+	528	WP_164455116.1	hypothetical protein	-
pBML2531_RS10520	2310234..2310485	+	252	WP_164455118.1	hypothetical protein	-
pBML2531_RS10525	2310620..2310979	+	360	WP_164456280.1	hypothetical protein	-
pBML2531_RS10530	2311106..2312080	+	975	WP_164455120.1	DUF1738 domain-containing protein	-
pBML2531_RS10535	2312090..2312395	+	306	WP_164455122.1	TA system toxin CbtA family protein	-
pBML2531_RS10540	2312448..2312765	-	318	WP_164455124.1	helix-turn-helix domain-containing protein	Antitoxin
pBML2531_RS10545	2312758..2313147	-	390	WP_164455126.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
pBML2531_RS10550	2313426..2314991	+	1566	WP_164455128.1	TraI domain-containing protein	-
pBML2531_RS10555	2315008..2316066	+	1059	WP_164455130.1	site-specific integrase	-
pBML2531_RS10565	2316574..2317647	-	1074	WP_004264664.1	membrane-bound lytic murein transglycosylase MltC	-
pBML2531_RS10570	2317702..2317971	-	270	WP_042848738.1	oxidative damage protection protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2255748..2316363	60615

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (3-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (49-90)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14340.61 Da
• Isoelectric Point: 6.3578

>T35490 WP_164455126.1 NZ_AP022372:c2313147-2312758 [Providencia rettgeri]
VGIYLTPEFEEERRSARISNAILCKAAKAIFSGLPGDPLGKFTYKKRLGLPGVGAKDGARSIVFFNNGENLFFFDMYLKS
ELSKKKGKELEADEINAYCNIAKDFIAMSSVMIKTLLTDKELIEVTCDD

Nucleotide

• Length: 390 bp

>T35490 NZ_AP022372:c2313147-2312758 [Providencia rettgeri]
GTGGGAATTTATTTAACACCTGAATTTGAGGAAGAACGCCGGAGCGCACGCATCAGTAATGCCATTTTGTGCAAAGCGGC
TAAAGCTATTTTTTCTGGTCTACCGGGCGATCCGCTAGGAAAATTCACCTACAAAAAGCGACTTGGCTTACCCGGAGTAG
GAGCGAAAGACGGTGCACGGTCAATTGTTTTTTTTAATAATGGCGAAAACCTATTTTTCTTTGATATGTATTTGAAAAGT
GAACTTTCCAAAAAGAAAGGAAAGGAGCTTGAAGCCGATGAAATTAATGCTTACTGCAATATCGCAAAAGATTTTATCGC
AATGAGTTCGGTAATGATAAAGACGTTGCTGACAGATAAAGAGCTGATTGAGGTGACTTGTGATGACTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11682.65 Da
• Isoelectric Point: 11.0022

>AT35490 WP_164455124.1 NZ_AP022372:c2312765-2312448 [Providencia rettgeri]
MTERLKRIQGMAERYNKLGVVRDETVAVIDAAVAARKIPAVRTMTGSQIKEVRTRYNMSQAALAMTTGMSVESVSKWERN
ESKPNKAALRIINIIDAKGPQVFMS

Nucleotide

• Length: 318 bp

>AT35490 NZ_AP022372:c2312765-2312448 [Providencia rettgeri]
ATGACTGAACGACTGAAACGCATTCAGGGCATGGCTGAGCGCTACAATAAATTAGGCGTGGTGAGAGATGAAACCGTCGC
GGTTATCGATGCTGCGGTCGCGGCCCGTAAAATACCGGCTGTCCGTACCATGACCGGTAGCCAGATTAAAGAAGTTCGCA
CTCGCTACAACATGTCACAAGCCGCACTGGCGATGACGACCGGCATGTCTGTAGAGAGTGTGTCGAAGTGGGAGAGAAAC
GAGAGCAAGCCGAACAAGGCCGCTTTGCGGATCATTAACATCATTGATGCTAAAGGGCCACAAGTATTTATGTCATAA